Oral diseases · 2026
Clinicopathological and Prognostic Features of Pleomorphic Adenoma, Recurrent Pleomorphic Adenoma, and Carcinoma ex Pleomorphic Adenoma: A 20-Year Retrospective Analysis.
СтатьяНазвание и аннотация: Перевод в очереди
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Kimura Talita de Carvalho, Lavareze Luccas, de Lima-Souza Reydson Alcides, Binda Nívia Castro, Chone Carlos Takahiro, Tincani Alfio José, Altemani Albina, Mariano Fernanda Viviane
Аннотация
BACKGROUND: Pleomorphic adenoma (PA) is the most common salivary gland tumor, and a subset may recur as recurrent PA (RPA) or progress to carcinoma ex pleomorphic adenoma (CXPA). However, comparative evaluations of their biological behavior and prognostic factors remain limited.
OBJECTIVE: To characterize and compare the clinical features, pathological patterns, treatment outcomes, and prognostic factors of PA, RPA, and CXPA over a 20-year period at a Brazilian tertiary referral center.
MATERIALS AND METHODS: A retrospective review of 234 cases (148 PA, 23 RPA, 63 CXPA) diagnosed between 2004 and 2024. Analyses included Fisher's exact test and chi-square test for group comparisons and Cox proportional hazards models for overall (OS) and disease-specific survival (DSS).
RESULTS: PA and RPA mainly affected younger females and presented smaller tumors and shorter clinical evolution than CXPA (p < 0.01). In CXPA, perineural invasion, angiolymphatic invasion, necrosis, recurrence, symptomatology, distant metastasis, and capsular invasion pattern were associated with reduced OS and DSS (p < 0.05).
CONCLUSION: This retrospective study demonstrates distinct clinical and pathological profiles across PA, RPA, and CXPA. In CXPA, clinical and histological factors strongly predict survival and should guide risk stratification, therapeutic decisions, and follow-up strategies.
OBJECTIVE: To characterize and compare the clinical features, pathological patterns, treatment outcomes, and prognostic factors of PA, RPA, and CXPA over a 20-year period at a Brazilian tertiary referral center.
MATERIALS AND METHODS: A retrospective review of 234 cases (148 PA, 23 RPA, 63 CXPA) diagnosed between 2004 and 2024. Analyses included Fisher's exact test and chi-square test for group comparisons and Cox proportional hazards models for overall (OS) and disease-specific survival (DSS).
RESULTS: PA and RPA mainly affected younger females and presented smaller tumors and shorter clinical evolution than CXPA (p < 0.01). In CXPA, perineural invasion, angiolymphatic invasion, necrosis, recurrence, symptomatology, distant metastasis, and capsular invasion pattern were associated with reduced OS and DSS (p < 0.05).
CONCLUSION: This retrospective study demonstrates distinct clinical and pathological profiles across PA, RPA, and CXPA. In CXPA, clinical and histological factors strongly predict survival and should guide risk stratification, therapeutic decisions, and follow-up strategies.