Enfermedades infecciosas y microbiologia clinica · 2011
Intestinal lymphangiectasia: an undescribed cause of malabsorption and incomplete immunological recovery in HIV-infected patients.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Marco-Lattur Maria D, Payeras Antoni, Campins Antoni A, Pons Jaume, Cifuentes Carmen, Riera Melcior
Аннотация
BACKGROUND: Although paradoxical virological and immunological response after HAART has been well studied, intestinal lymphangiectasia (IL) in HIV-1 infected patients has not previously described.
METHODS: To describe HIV patients who developed IL.
DESIGN: Clinical Case series.
PATIENTS: 4 patients with HIV and IL diagnosis based on clinical, endoscopic and pathological findings.
RESULTS: All four cases had prior mycobacterial infections with abdominal lymph node involvement and a very low CD4 cell count nadir. They developed intestinal lymphangiectasia despite appropriate virological suppression with HAART and repeatedly negative mycobacterial cultures. Two patients were clinically symptomatic with oedemas, ascites, diarrhoea, asthenia, weight loss; but the other two were diagnosed with malabsorption as a result of laboratory findings, with hypoproteinemia and hypoalbuminemia. Three of them were diagnosed by video capsule endoscopy.
CONCLUSIONS: IL should be considered in HIV-1 infected patients who present with clinical or biochemical malabsorption parameters when there is no immunological recovery while on HAART.
METHODS: To describe HIV patients who developed IL.
DESIGN: Clinical Case series.
PATIENTS: 4 patients with HIV and IL diagnosis based on clinical, endoscopic and pathological findings.
RESULTS: All four cases had prior mycobacterial infections with abdominal lymph node involvement and a very low CD4 cell count nadir. They developed intestinal lymphangiectasia despite appropriate virological suppression with HAART and repeatedly negative mycobacterial cultures. Two patients were clinically symptomatic with oedemas, ascites, diarrhoea, asthenia, weight loss; but the other two were diagnosed with malabsorption as a result of laboratory findings, with hypoproteinemia and hypoalbuminemia. Three of them were diagnosed by video capsule endoscopy.
CONCLUSIONS: IL should be considered in HIV-1 infected patients who present with clinical or biochemical malabsorption parameters when there is no immunological recovery while on HAART.