MedElevator Войти в исследования
← Поиск публикаций

DOI 10.1038/s41467-023-36997-w

Медицинская библиотека · Nature communications · 2023

Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease.

Young William J, Haessler Jeffrey, Benjamins Jan-Walter, Repetto Linda, Yao Jie, Isaacs Aaron, Harper Andrew R, Ramirez Julia, Garnier Sophie, van Duijvenboden Stefan, Baldassari Antoine R, Concas Maria Pina, Duong ThuyVy, Foco Luisa, Isaksen Jonas L, Mei Hao, Noordam Raymond, Nursyifa Casia, Richmond Anne, Santolalla Meddly L, Sitlani Colleen M, Soroush Negin, Thériault Sébastien, Trompet Stella, Aeschbacher Stefanie, Ahmadizar Fariba, Alonso Alvaro, Brody Jennifer A, Campbell Archie, Correa Adolfo, Darbar Dawood, De Luca Antonio, Deleuze Jean-François, Ellervik Christina, Fuchsberger Christian, Goel Anuj, Grace Christopher, Guo Xiuqing, Hansen Torben, Heckbert Susan R, Jackson Rebecca D, Kors Jan A, Lima-Costa Maria Fernanda, Linneberg Allan, Macfarlane Peter W, Morrison Alanna C, Navarro Pau, Porteous David J, Pramstaller Peter P, Reiner Alexander P, Risch Lorenz, Schotten Ulrich, Shen Xia, Sinagra Gianfranco, Soliman Elsayed Z, Stoll Monika, Tarazona-Santos Eduardo, Tinker Andrew, Trajanoska Katerina, Villard Eric, Warren Helen R, Whitsel Eric A, Wiggins Kerri L, Arking Dan E, Avery Christy L, Conen David, Girotto Giorgia, Grarup Niels, Hayward Caroline, Jukema J Wouter, Mook-Kanamori Dennis O, Olesen Morten Salling, Padmanabhan Sandosh, Psaty Bruce M, Pattaro Cristian, Ribeiro Antonio Luiz P, Rotter Jerome I, Stricker Bruno H, van der Harst Pim, van Duijn Cornelia M, Verweij Niek, Wilson James G, Orini Michele, Charron Philippe, Watkins Hugh, Kooperberg Charles, Lin Henry J, Wilson James F, Kanters Jørgen K, Sotoodehnia Nona, Mifsud Borbala, Lambiase Pier D, Tereshchenko Larisa G, Munroe Patricia B

СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry genome-wide association studies we identify 61 (58 previously unreported) loci for the spatial QRS-T angle (N = 118,780) and 11 for the frontal QRS-T angle (N = 159,715). Seven out of the 61 spatial QRS-T angle loci have not been reported for other electrocardiographic measures. Enrichments are observed in pathways related to cardiac and vascular development, muscle contraction, and hypertrophy. Pairwise genome-wide association studies with classical ECG traits identify shared genetic influences with PR interval and QRS duration. Phenome-wide scanning indicate associations with atrial fibrillation, atrioventricular block and arterial embolism and genetically determined QRS-T angle measures are associated with fascicular and bundle branch block (and also atrioventricular block for the frontal QRS-T angle). We identify potential biology involved in the QRS-T angle and their genetic relationships with cardiovascular traits and diseases, may inform future research and risk prediction.

Для цитирования: Young William J, Haessler Jeffrey, Benjamins Jan-Walter, Repetto Linda, Yao Jie, Isaacs Aaron, Harper Andrew R, Ramirez Julia, Garnier Sophie, van Duijvenboden Stefan, Baldassari Antoine R, Concas Maria Pina, Duong ThuyVy, Foco Luisa, Isaksen Jonas L, Mei Hao, Noordam Raymond, Nursyifa Casia, Richmond Anne, Santolalla Meddly L, Sitlani Colleen M, Soroush Negin, Thériault Sébastien, Trompet Stella, Aeschbacher Stefanie, Ahmadizar Fariba, Alonso Alvaro, Brody Jennifer A, Campbell Archie, Correa Adolfo, Darbar Dawood, De Luca Antonio, Deleuze Jean-François, Ellervik Christina, Fuchsberger Christian, Goel Anuj, Grace Christopher, Guo Xiuqing, Hansen Torben, Heckbert Susan R, Jackson Rebecca D, Kors Jan A, Lima-Costa Maria Fernanda, Linneberg Allan, Macfarlane Peter W, Morrison Alanna C, Navarro Pau, Porteous David J, Pramstaller Peter P, Reiner Alexander P, Risch Lorenz, Schotten Ulrich, Shen Xia, Sinagra Gianfranco, Soliman Elsayed Z, Stoll Monika, Tarazona-Santos Eduardo, Tinker Andrew, Trajanoska Katerina, Villard Eric, Warren Helen R, Whitsel Eric A, Wiggins Kerri L, Arking Dan E, Avery Christy L, Conen David, Girotto Giorgia, Grarup Niels, Hayward Caroline, Jukema J Wouter, Mook-Kanamori Dennis O, Olesen Morten Salling, Padmanabhan Sandosh, Psaty Bruce M, Pattaro Cristian, Ribeiro Antonio Luiz P, Rotter Jerome I, Stricker Bruno H, van der Harst Pim, van Duijn Cornelia M, Verweij Niek, Wilson James G, Orini Michele, Charron Philippe, Watkins Hugh, Kooperberg Charles, Lin Henry J, Wilson James F, Kanters Jørgen K, Sotoodehnia Nona, Mifsud Borbala, Lambiase Pier D, Tereshchenko Larisa G, Munroe Patricia B. Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease.. Nature communications. 2023. DOI: 10.1038/s41467-023-36997-w.

Предметные рубрики MeSH

HumansCardiovascular DiseasesAtrioventricular BlockGenome-Wide Association StudyRisk FactorsArrhythmias, CardiacElectrocardiographyBiomarkers
Подготовка и перевод публикации
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.

Тип публикации указан по данным источника. Уровень доказательности автоматически не присваивается.