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Войти в исследования Laboratory medicine · 2026
Acquired bisalbuminemia associated with hepatobiliary disease: a two-case report and diagnostic implications.
СтатьяКлинический случайНазвание и аннотация: Перевод в очереди
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Karami Reda, El Boukhrissi Fatima
Аннотация
INTRODUCTION: Acquired bisalbuminemia is an uncommon qualitative albumin abnormality increasingly detected by capillary electrophoresis. It can be associated with several pathologic contexts.
METHODS: A retrospective analysis was performed on two cases of bisalbuminemia detected over a 10-year period in the biochemistry-toxicology laboratory of Moulay Ismail Military Hospital in Meknes, Morocco. Clinical, biochemical, electrophoretic, and histologic data were reviewed, with particular emphasis on serum albumin electrophoretic patterns.
RESULTS: Bisalbuminemia was identified in two distinct hepatobiliary contexts: an overlap syndrome between autoimmune hepatitis and primary sclerosing cholangitis and antibiotic exposure in a patient with cholangiocarcinoma. In both cases, the abnormal albumin fraction was temporary and resolved after treating the underlying condition or withdrawing the drug that was causing it.
DISCUSSION: Acquired bisalbuminemia represents a reversible laboratory finding that reflects underlying pathologic or pharmacologic processes. Capillary electrophoresis plays a pivotal role in the detection and follow-up of this condition.
METHODS: A retrospective analysis was performed on two cases of bisalbuminemia detected over a 10-year period in the biochemistry-toxicology laboratory of Moulay Ismail Military Hospital in Meknes, Morocco. Clinical, biochemical, electrophoretic, and histologic data were reviewed, with particular emphasis on serum albumin electrophoretic patterns.
RESULTS: Bisalbuminemia was identified in two distinct hepatobiliary contexts: an overlap syndrome between autoimmune hepatitis and primary sclerosing cholangitis and antibiotic exposure in a patient with cholangiocarcinoma. In both cases, the abnormal albumin fraction was temporary and resolved after treating the underlying condition or withdrawing the drug that was causing it.
DISCUSSION: Acquired bisalbuminemia represents a reversible laboratory finding that reflects underlying pathologic or pharmacologic processes. Capillary electrophoresis plays a pivotal role in the detection and follow-up of this condition.