Nature communications · 2026
Cell type-specific enhancers regulate IL-22 expression in innate and adaptive type 3 lymphoid cells.
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Saini Ankita, Hopkins Leone S, Serna Vanida A, McCullen Matthew V D, Selner Nicholas G, Bhattarai Bishan, Fachi José L, Glynn Rebecca A, Hayer Katharina E, Bassing Craig H, Colonna Marco, Oltz Eugene M
Аннотация
IL-22, a signature cytokine for type 3 lymphoid cells, including T helper 17/22 (Th17/22) and type 3 innate lymphoid cells (ILC3), mediates epithelial homeostasis and protective pathogen responses in barrier tissues. Upon dysregulation, IL-22 can drive chronic inflammatory diseases, yet little is known about transcriptional elements modulating its expression. Here, we identify two enhancers, E22-1 and E22-2, with distinct capacities for regulating Il22 expression in type 3 lymphoid cells. Both enhancers are necessary for protection from Citrobacter rodentium infection and for the onset of IL-22-mediated psoriasis. E22-2 is specifically required for IL-22 expression in ILC3s, while E22-1 functions in both Th17/22 and ILC3. The ILC3 specificity of E22-2 is attributed to the presence of multiple Runx3 sites and the lack of a functional RORγt motif. We conclude that Th17/22 and ILC3 cells use distinct cis-elements to differentially regulate IL-22 expression, while orchestrating homeostatic protection and pathogen defense in barrier tissues.