Human genomics · 2026
Editing regulatory network in non-small cell lung cancer: implications for immunity and metastasis.
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Zhang Jiajin, Huang Liyu, Wu Sijia
Аннотация
BACKGROUND: RNA editing plays critical roles in cancer development, and multiple editing events collectively exert greater effects than individual events. However, the coordinated impact of RNA editing remains poorly understood.
METHODS: A comprehensive framework was proposed to investigate interactions among RNA editing events, capturing both the global editing landscape and site-specific functional effects. The resulting RNA editing modules were further explored to reveal gene interactions and regulatory mechanisms from the perspective of RNA editing.
RESULTS: Using non-small cell lung cancer as an example, we identified more than 12 modules involved in immune regulation and metastasis-related processes, demonstrating their clinical relevance. Mechanistically, RNA editing influenced miRNA-mediated regulation of EIF2AK2 and PRKAR2A, transcription factor activity of AHR, and RNA-binding regulation of DDX3X, highlighting its role in shaping gene regulatory networks.
CONCLUSIONS: Collectively, this study provides a systematic, module-based framework for understanding coordinated RNA editing, offering new insights into RNA editing-mediated gene interactions and revealing a complementary approach to study molecular mechanisms of diseases.
METHODS: A comprehensive framework was proposed to investigate interactions among RNA editing events, capturing both the global editing landscape and site-specific functional effects. The resulting RNA editing modules were further explored to reveal gene interactions and regulatory mechanisms from the perspective of RNA editing.
RESULTS: Using non-small cell lung cancer as an example, we identified more than 12 modules involved in immune regulation and metastasis-related processes, demonstrating their clinical relevance. Mechanistically, RNA editing influenced miRNA-mediated regulation of EIF2AK2 and PRKAR2A, transcription factor activity of AHR, and RNA-binding regulation of DDX3X, highlighting its role in shaping gene regulatory networks.
CONCLUSIONS: Collectively, this study provides a systematic, module-based framework for understanding coordinated RNA editing, offering new insights into RNA editing-mediated gene interactions and revealing a complementary approach to study molecular mechanisms of diseases.