Evaluation of apelin, chemerin, leptin, resistin and vaspin levels in patients with obstructive sleep apnoea syndrome.

BACKGROUND

The aim of this study was to investigate serum levels of apelin, chemerin, leptin, resistin, vaspin and advanced glycation end-products (AGEs) relationships with Obstructive Sleep Apnea Syndrome (OSA).

METHODS

54 OSA patients and 34 healthy controls participated in this study. The levels of chemerin, leptin, resistin, vaspin and AGEs were determined in the serum by the ELISA method.

RESULTS

The chemerin median values were significantly higher (p = 0,012) in the patients group when compared with the control. In contrast, the mean of AGEs in the patient’s group was significantly decreased compared to the control group (p = 0.036). A positive correlation was found between chemerin and apnea-hypopnea index (AHI) (r = 304, p = 0.025) and oxygen desaturation index (ODI) (r = 0.278, p = 0.042). A correlation was also observed among chemerin and haemoglobin (r = 0.228, p = 0.032) and iron (r = 0.339, p = 001). There was a positive correlation between apelin and C-reactive protein (CRP) (r = 0.226, p = 0.034). Leptin was positively correlated with body mass index (BMI), glucose, insulin, HbA1c, haemoglobin and iron.

CONCLUSIONS

The result of this study demonstrate that chemerin and AGEs are related to OSA physiopathology. These two parameters may help in the diagnosis and progress of sleep apnea.