A typical presentation of AMSAN variant of guillain-barré syndrome in an elderly female with multisystem involvement: A case report.

Guillain-Barré Syndrome (GBS) is an acute immune-mediated polyradiculoneuropathy, with the AMSAN (Acute Motor and Sensory Axonal Neuropathy) variant representing a severe subtype characterized by rapid progression and poor prognosis. This report describes a 68-year-old woman presenting with progressive quadriparesis, cranial nerve involvement, and bowel and respiratory complications, ultimately diagnosed as AMSAN based on nerve conduction studies and cerebrospinal fluid analysis. MRI and EEG findings contributed to the diagnostic complexity due to age-related degenerative and vascular changes. Despite early IVIg administration, the patient required intensive care, emphasizing the need for prompt diagnosis and multidisciplinary management. AMSAN in elderly patients demands high clinical vigilance and early neurophysiological evaluation to initiate timely immunotherapy and improve outcomes.