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Войти в исследования Journal of infection and public health · 2026
Baseline epidemiology study of nasopharyngeal carriage and serotypes of Streptococcus pneumoniae in children aged 6-59 months prior to the introduction of pneumococcal conjugate vaccine in Iran.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Rohani Mahdi, Ashrafian Fatemeh, Sorouri Rahim, Velayati Ali Akbar, Sayyahfar Shirin, Pournasiri Zahra, Karimi Abdollah, Rafiei Tabatabaei Sedigheh, Azimi Leila, Esteghamati Abdoulreza, Fahimzad Alireza, Banifazl Mohammad, Parzadeh Masoumeh, Abdollahi Sara, Haji Maghsoudi Saiedeh, Bavand Anahita, Sadat Larijani Mona, Eybpoosh Sana, Ramezannejad Mojgan, Zali Mahsan, Tajmehrabi Namini Parinaz, Moradi Ladan, Doroud Delaram, Ramezani Amitis
Аннотация
BACKGROUND AND AIM: This study aimed to assess the prevalence, serotype distribution, and antimicrobial susceptibility of Streptococcus pneumoniae (S. pneumoniae) in children aged 6-59 months in Iran, prior to introducing pneumococcal conjugate vaccine (PCV).
METHODS: Nasopharyngeal (NP) samples were collected from unvaccinated children aged 6-59 months in this multicenter study. S. pneumoniae was identified using culture methods along with biochemical characteristics and confirmed by real-time PCR. Antibiotic resistance testing was performed utilizing the MIC method. Serotyping was accomplished through the utilization of the Quellung test.
RESULTS: Of the 1063 nasopharynx isolates, 20.4% carried pneumococcus in NP. The five most common isolated serotypes were 23 F, 19 F, 14, 15B and 6 A. High frequency of 15B, as non-vaccine serotypes (NVTs), was observed. Approximately 20% of the isolates were non-susceptible to penicillin, while low resistance rates were recorded against ceftriaxone (8.7%). Overall, 25.4% of pneumococcal strains exhibited multidrug resistance (MDR). The serotype coverage of PCV7, PCV10, and PCV13 were determined as 42.5%, 54.7%, and 61.8%, respectively.
CONCLUSIONS: S. pneumoniae was detected in 20.4% Iranian children's NP samples, with the serotype 23 F dominancy. Emerging of 15B and lower PCVs prediction coverage compared to other unvaccinated countries, might stem from limited administration of PCV13, environmental/epidemiological factors, and COVID-19-related shifts in colonization. Ongoing surveillance of pneumococcal carriage, serotype distribution, and antimicrobial resistance are required due to the existence of antibiotic resistance and MDR isolates.
METHODS: Nasopharyngeal (NP) samples were collected from unvaccinated children aged 6-59 months in this multicenter study. S. pneumoniae was identified using culture methods along with biochemical characteristics and confirmed by real-time PCR. Antibiotic resistance testing was performed utilizing the MIC method. Serotyping was accomplished through the utilization of the Quellung test.
RESULTS: Of the 1063 nasopharynx isolates, 20.4% carried pneumococcus in NP. The five most common isolated serotypes were 23 F, 19 F, 14, 15B and 6 A. High frequency of 15B, as non-vaccine serotypes (NVTs), was observed. Approximately 20% of the isolates were non-susceptible to penicillin, while low resistance rates were recorded against ceftriaxone (8.7%). Overall, 25.4% of pneumococcal strains exhibited multidrug resistance (MDR). The serotype coverage of PCV7, PCV10, and PCV13 were determined as 42.5%, 54.7%, and 61.8%, respectively.
CONCLUSIONS: S. pneumoniae was detected in 20.4% Iranian children's NP samples, with the serotype 23 F dominancy. Emerging of 15B and lower PCVs prediction coverage compared to other unvaccinated countries, might stem from limited administration of PCV13, environmental/epidemiological factors, and COVID-19-related shifts in colonization. Ongoing surveillance of pneumococcal carriage, serotype distribution, and antimicrobial resistance are required due to the existence of antibiotic resistance and MDR isolates.