Candidozyma auris (formerly Candida auris) in the acute care environment: Identifying and controlling transmission through a systematic investigation in an academic hospital.

A nosocomial Candidozyma auris (formerly Candida auris) outbreak affecting cardiac surgery patients prompted implementation of a multifaceted infection prevention strategy in a large academic hospital. Interventions included an expanded epidemiological line listing, enhanced surveillance, environmental culturing, whole-genome sequencing, and implementation of an in-house polymerase chain reaction assay. This integrated approach achieved sustained interruption of transmission in a high-risk cardiac population and provides an adaptable model for outbreak investigation in high-acuity settings.