Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2022
Efficacy of cytapheresis for induction therapy and extra-intestinal skin manifestations of ulcerative colitis.
СтатьяНазвание и аннотация: Перевод в очереди
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Shibuya Tomoyoshi, Nomura Osamu, Nomura Kei, Haraikawa Mayuko, Haga Keiichi, Ishikawa Dai, Osada Taro, Yamaji Ken, Ikeda Shigaku, Nagahara Akihito
Аннотация
INTRODUCTION: In recent years, the prevalence of inflammatory bowel diseases has been increasing in Japan due to the westernization of lifestyles. Many patients have been reported to have extra-intestinal manifestations (EIMs) at least once. Skin lesions occur with a high degree of frequency among EIMs, with erythema nodosum (EN) and pyoderma gangrenosum (PG) the main complications. Cytapheresis is again attracting attention as a treatment with few side effects.
METHODS: We investigated the therapeutic effect of cytapheresis on ulcerative colitis (UC) and cutaneous EIMs. Between 2008 and 2021, 240 patients with active UC had induction therapy by cytapheresis at our hospital.
RESULTS: Remission and response rates were 50.0% and 67.5%, respectively. Apheresis was performed on seven patients with PG and five patients with EN with a good response. Serious adverse events were not observed.
CONCLUSION: This retrospective assessment of efficacy showed that EN and PG responded favorably to cytapheresis.
METHODS: We investigated the therapeutic effect of cytapheresis on ulcerative colitis (UC) and cutaneous EIMs. Between 2008 and 2021, 240 patients with active UC had induction therapy by cytapheresis at our hospital.
RESULTS: Remission and response rates were 50.0% and 67.5%, respectively. Apheresis was performed on seven patients with PG and five patients with EN with a good response. Serious adverse events were not observed.
CONCLUSION: This retrospective assessment of efficacy showed that EN and PG responded favorably to cytapheresis.