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DOI 10.21873/anticanres.14946

Медицинская библиотека · Anticancer research · 2021

Sinusoidal Obstruction Syndrome Promotes Liver Metastatic Seeding of Colorectal Cancer Cells in a Rat Model.

Nishino Hiroto, Okuno Masayuki, Seo Satoru, Toda Rei, Yoshino Kenji, Kasai Yosuke, Satoh Motohiko, Iwaisako Keiko, Taura Kojiro, Hatano Etsuro

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Аннотация

BACKGROUND/AIM: Sinusoidal obstruction syndrome (SOS) after neoadjuvant chemotherapy with oxaliplatin for colorectal liver metastases (CRLM) has been reported to lead to early recurrence. This study investigated the effects of SOS on the development of CRLM in a rat model.

MATERIALS AND

METHODS

RCN-H4 cells were injected into the spleen or liver of ten monocrotaline-treated (SOS group) and ten untreated (control group) rats. The number and size of liver tumors were compared between the groups.

RESULTS

The number of liver tumors in the splenic RCN-H4 injection model was significantly higher in the SOS group than in the control group (332±213 vs. 16±5, p=0.029); however, the largest tumor diameter in the hepatic model was similar between groups (6.2±1.8 vs. 6.4±2.4 mm, p=0.87).

CONCLUSION

SOS promotes CRLM development by splenic RCN-H4 cell injection. This might be due to the higher incidence of cancer cell implantation into the liver.

Для цитирования: Nishino Hiroto, Okuno Masayuki, Seo Satoru, Toda Rei, Yoshino Kenji, Kasai Yosuke, Satoh Motohiko, Iwaisako Keiko, Taura Kojiro, Hatano Etsuro. Sinusoidal Obstruction Syndrome Promotes Liver Metastatic Seeding of Colorectal Cancer Cells in a Rat Model.. Anticancer research. 2021. DOI: 10.21873/anticanres.14946.

Предметные рубрики MeSH

AnimalsCell Line, TumorColorectal NeoplasmsDisease Models, AnimalDisease ProgressionGene Expression Regulation, NeoplasticHepatic Veno-Occlusive DiseaseIntercellular Adhesion Molecule-1Liver NeoplasmsMaleMatrix Metalloproteinase 9MonocrotalineRats, Inbred F344Tumor BurdenVascular Endothelial Growth Factor ARats
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