Next-Generation Drug Delivery Systems and Drugs for Vascular Intervention.

Coronary and peripheral endovascular revascularization has advanced far beyond plain old balloon angioplasty and bare metal stents. Modern revascularization approaches now utilize new-generation antiproliferative drugs that are delivered from drug-eluting stents and balloons using complex nanotechnology. Despite these contemporary approaches, neointimal hyperplasia continues to pose challenges in the form of stent thrombosis and in-stent restenosis, infrequently requiring reintervention. Fortunately, there is tireless ongoing work aiming to improve our current anti-restenosis agents and drug delivery platforms. This review aims to summarize the state of our therapeutics and drug delivery systems while also highlighting promising areas of next-generation technological development.