The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2026
Predictive value of serum IGFBP-3 and transvaginal cervical length measurement for spontaneous preterm birth in singleton pregnancies: a prospective study.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Mhernchan Supakit, Phupong Vorapong
Аннотация
OBJECTIVE: To determine the predictive value of serum IGFBP-3 in combination with transvaginal ultrasonography cervical length in singleton pregnancies during the 18-23+6 weeks' gestational period for the prediction of preterm birth.
METHODS: This prospective observational study included singleton pregnant women who received antenatal care at King Chulalongkorn Memorial Hospital at 18-23+6 weeks' gestation between December 2022 and April 2024. Cervical length was determined by transvaginal ultrasound and serum was collected to measure IGFBP-3 levels. Demographic data and pregnancy outcomes were recorded.
RESULTS: A total of 176 pregnant women were analyzed. Twelve cases (6.8%) of preterm births were identified. Preterm birth prediction, when using serum IGFBP-3 values greater than 6.9 ng/ml, had a sensitivity of 75%, a specificity of 61.5%, a positive predictive value (PPV) of 12.3% and a negative predictive value (NPV) of 97.1%. When cervical length values less than 37 mm were used, the prediction had a sensitivity of 66.7%, a specificity of 44.6%, a PPV of 8%, and a NPV of 94.9%. When serum IGFBP-3 or cervical length was used to predict preterm birth, sensitivity, specificity, PPV and NPV were 83.3%, 27.1%, 7.6% and 95.7%, respectively.
CONCLUSIONS: The use of serum IGFBP-3 levels in combination with cervical length had a good sensitivity to predict preterm birth. While NPV is high, the low PPV limits its standalone use to predict preterm birth.
METHODS: This prospective observational study included singleton pregnant women who received antenatal care at King Chulalongkorn Memorial Hospital at 18-23+6 weeks' gestation between December 2022 and April 2024. Cervical length was determined by transvaginal ultrasound and serum was collected to measure IGFBP-3 levels. Demographic data and pregnancy outcomes were recorded.
RESULTS: A total of 176 pregnant women were analyzed. Twelve cases (6.8%) of preterm births were identified. Preterm birth prediction, when using serum IGFBP-3 values greater than 6.9 ng/ml, had a sensitivity of 75%, a specificity of 61.5%, a positive predictive value (PPV) of 12.3% and a negative predictive value (NPV) of 97.1%. When cervical length values less than 37 mm were used, the prediction had a sensitivity of 66.7%, a specificity of 44.6%, a PPV of 8%, and a NPV of 94.9%. When serum IGFBP-3 or cervical length was used to predict preterm birth, sensitivity, specificity, PPV and NPV were 83.3%, 27.1%, 7.6% and 95.7%, respectively.
CONCLUSIONS: The use of serum IGFBP-3 levels in combination with cervical length had a good sensitivity to predict preterm birth. While NPV is high, the low PPV limits its standalone use to predict preterm birth.