Science (New York, N.Y.) · 2025
Attenuation of virulence in Yersinia pestis across three plague pandemics.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Sidhu Ravneet Kaur, Mas Fiol Guillem, Lê-Bury Pierre, Demeure Christian E, Bougit Emelyne, Beau Rémi, Balière Charlotte, Kwasiborski Aurelia, Caro Valérie, Klunk Jennifer, Salkeld Daniel J, Carmichael Ann, Varlık Nükhet, Poinar Debi, Earn David J D, Bolker Benjamin M, Dushoff Jonathan, Golding G Brian, Rascovan Nicolas, Dussurget Olivier, Holmes Edward C, Pizarro-Cerdá Javier, Poinar Hendrik N
Аннотация
Yersinia pestis has spilled over from wild rodent reservoirs to commensal rodents and humans, causing three historically recorded pandemics. Depletion in the copy number of the plasmid-encoded virulence gene pla occurred in later-dated strains of the first and second pandemics, yet the biological relevance of the pla deletion has been difficult to test. We identified modern Y. pestis strains that independently acquired the same pla depletion as ancient strains and herein show that excision of pla from the multicopy pPCP1 plasmid is accompanied by the integration of a separate full pPCP1 harboring pla into the single-copy pCD1 plasmid, reducing pla dosage. Moreover, we demonstrate that this depletion decreases the mortality of mice in models of bubonic plague but not in the pneumonic and septicemic forms of the disease. We hypothesize that pla depletion may have been selectively advantageous in bubonic plague, owing to rodent fragmentation after pandemic-induced mortality.