Ocular immunology and inflammation · 2020

The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Review of 447 Patients with Tubercular Intermediate Uveitis and Panuveitis.

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Agrawal Rupesh, Betzler Bjorn Kaijun, Testi Ilaria, Mahajan Sarakshi, Agarwal Aniruddha, Gunasekeran Dinesh Visva, Raje Dhananjay, Aggarwal Kanika, Murthy Somasheila I, Westcott Mark, Chee Soon-Phaik, McCluskey Peter, Ho Su Ling, Teoh Stephen, Cimino Luca, Biswas Jyotirmay, Narain Shishir, Agarwal Manisha, Mahendradas Padmamalini, Khairallah Moncef, Jones Nicholas, Tugal-Tutkun Ilknur, Babu Kalpana, Basu Soumayava, Carreño Ester, Lee Richard, Al-Dhibi Hassan, Bodaghi Bahram, Invernizzi Alessandro, Goldstein Debra A, Barisani-Asenbauer Talin, González-López Julio J, Androudi Sofia, Bansal Reema, Moharana Bruttendu, Esposti Simona Degli, Tasiopoulou Anastasia, Nadarajah Sengal, Agarwal Mamta, Abraham Sharanaya, Vala Ruchi, Singh Ramandeep, Sharma Aman, Sharma Kusum, Zierhut Manfred, Kon Onn Min, Cunningham Emmett T, Kempen John H, Nguyen Quan Dong, Pavesio Carlos, Gupta Vishali

Аннотация

Purpose: Tubercular intermediate uveitis (TIU) and panuveitis (TBP) are difficult to manage because of limitations in diagnostic tools and lack of evidence-based treatment guidelines. The Collaborative Ocular Tuberculosis Study (COTS) analyzed treatment regimens and therapeutic outcomes in patients with TIU and TBP.Methods: Multicentre retrospective analysis.Results A total of 138 TIU and 309 TBP patients were included. A total of 382 subjects received antitubercular therapy (ATT) (n = 382/447; 85.4%) and 382 received corticosteroids (n = 382/447; 85.4%). Treatment failure was observed in 78 individuals (n = 78/447; 17.4%), occurring less frequently in patients receiving ATT (n = 66/382; 17.2%) compared to those who did not (n = 12/65; 18.5%). The study did not show any statistically significant therapeutic effect of ATT in patients with TIU and TBP.Conclusion Taking into account the limitations of the retrospective, non-randomized study design, resultant reliance on reported data records, and unequal size of the samples, the current study cannot provide conclusive evidence on the therapeutic benefit of ATT in TIU and TBP.

The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Review of 447 Patients with Tubercular Intermediate Uveitis and Panuveitis.

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