Biomarkers of Reversible and Irreversible Pulpitis: Systematic Review and Meta-Analysis.

This study aimed to identify biomarkers that could enhance the accuracy of diagnosing reversible and irreversible pulpitis. This systematic review was conducted in adherence to the guidelines outlined in PRISMA. A total of twelve studies were included for analysis. A meta-analysis of nine studies showed an overall effect of 9.91 with a P value of less than 0.00001. Eight out of the nine studies favored the control group. The studies exhibited substantial variation, with an I-square value of 99%, indicating significant heterogeneity (P < 0.00001). According to this systemic review, the expression of IL-8, TNF-a, MMP-9, and RAGE gene and protein was increased in pulp samples from teeth clinically diagnosed with irreversible symptomatic pulpitis.