The Traditional Applications, Phytochemistry, Pharmacology, Pharmacokinetics, Quality Control and Safety of Paeoniae Radix Alba: A Review.

Paeoniae Radix Alba (PRA, called Baishao in China) is the dried root of Paeonia lactiflora Pall. In clinical practice, PRA has been used to treat cardiovascular disease, menstrual disorders, abdominal pain, diarrhea, and liver disease, among other conditions. This review provides a systematic summary of its traditional uses, geographical distribution and current cultivation situation, phytochemistry, pharmacokinetics, pharmacology, quality control, and toxicology. Moreover, this review also serves as an in-depth discussion on the shortcomings of the current research on PRA, a subject not previously discussed in reviews regarding PRA, and puts forward its own views and solutions. So far, more needs to be done to understand the mechanism of action of PRA, as well as the relationships between its chemical components and their potential synergistic and antagonistic effects. Furthermore, a comprehensive evaluation of medicinal quality should be carried out to understand the long-term in vivo toxicity and clinical efficacy of PRA and to provide more information for the development of new drugs and treatment methods for various diseases using PRA and its chemical components.