Dermatitis : contact, atopic, occupational, drug · 2006
Cross-reactions among parabens, para-phenylenediamine, and benzocaine: a retrospective analysis of patch testing.
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Turchin Irina, Moreau Linda, Warshaw Erin, Sasseville Denis
Аннотация
BACKGROUND: Parabens are alkyl ester derivatives of para-hydroxybenzoic acid and are the most commonly used preservatives in the cosmetic industry. Cross-reactions with para-amino compounds, namely, benzocaine and para-phenylenediamine (PPD), have been reported but are thought to be extremely rare.
OBJECTIVE: To evaluate the rate of cross-reactivity between parabens, PPD, and benzocaine in a population of patients patch-tested in a hospital-based contact dermatitis clinic.
METHODS: A retrospective analysis of 4,368 patients consecutively patch-tested between July 1989 and June 2005.
RESULTS: Our study demonstrated that the rate of cross-reactions to parabens in PPD- and benzocaine-positive patients combined is 2%.
CONCLUSION: This cross-reaction rate is significant in the tested population but still falls within the previously reported rates of sensitivity to parabens in the general population (0 to 3.5%).
OBJECTIVE: To evaluate the rate of cross-reactivity between parabens, PPD, and benzocaine in a population of patients patch-tested in a hospital-based contact dermatitis clinic.
METHODS: A retrospective analysis of 4,368 patients consecutively patch-tested between July 1989 and June 2005.
RESULTS: Our study demonstrated that the rate of cross-reactions to parabens in PPD- and benzocaine-positive patients combined is 2%.
CONCLUSION: This cross-reaction rate is significant in the tested population but still falls within the previously reported rates of sensitivity to parabens in the general population (0 to 3.5%).