Developmental dynamics : an official publication of the American Association of Anatomists · 2014
R-spondins/Lgrs expression in tooth development.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Kawasaki Maiko, Porntaveetus Thantrira, Kawasaki Katsushige, Oommen Shelly, Otsuka-Tanaka Yoko, Hishinuma Mitsue, Nomoto Takato, Maeda Takeyasu, Takubo Keiyo, Suda Toshio, Sharpe Paul T, Ohazama Atsushi
Аннотация
BACKGROUND: Tooth development is highly regulated in mammals and it is regulated by networks of signaling pathways (e. g. Tnf, Wnt, Shh, Fgf and Bmp) whose activities are controlled by the balance between ligands, activators, inhibitors and receptors. The members of the R-spondin family are known as activators of Wnt signaling, and Lgr4, Lgr5, and Lgr6 have been identified as receptors for R-spondins. The role of R-spondin/Lgr signaling in tooth development, however, remains unclear.
RESULTS: We first carried out comparative in situ hybridization analysis of R-spondins and Lgrs, and identified their dynamic spatio-temporal expression in murine odontogenesis. R-spondin2 expression was found both in tooth germs and the tooth-less region, the diastema. We further examined tooth development in R-spondin2 mutant mice, and although molars and incisors exhibited no significant abnormalities, supernumerary teeth were observed in the diastema.
CONCLUSIONS: R-spondin/Lgr signaling is thus involved in tooth development.
RESULTS: We first carried out comparative in situ hybridization analysis of R-spondins and Lgrs, and identified their dynamic spatio-temporal expression in murine odontogenesis. R-spondin2 expression was found both in tooth germs and the tooth-less region, the diastema. We further examined tooth development in R-spondin2 mutant mice, and although molars and incisors exhibited no significant abnormalities, supernumerary teeth were observed in the diastema.
CONCLUSIONS: R-spondin/Lgr signaling is thus involved in tooth development.