Медицинская библиотека · Liver international : official journal of the International Association for the Study of the Liver · 2026

CHAIN Cohort: Prospective Multicenter Study of MASLD With Serial Liver Stiffness Assessments in Cardiovascular Care.

Zhou Xiao-Dong, Fan Ren Cheng-Han, Chen Jian-Dong, Zhou Xi-Qiao, Tong Qian, Gao Yan-Hang, Wang Xiao-Qi, Jiang Ya-Kun, Pu Xiang-Yuan, Shi Yu, Wang Ming-Wei, Liu Jing, Jiang Hai-Bing, Ma Li, Zhang Xin-Gang, Li Yi-Ling, Lin Su, Yang Hong-Ju, Song Yao-Hong, Zhang Yan-Liang, Lu Cheng-Zhi, Wang Feng-Mei, Shen De-Liang, Liang Hong-Xia, Luo Qiang, Chen En-Qiang, Li Bo, Zhong Bi-Hui, Liu Ying-Wu, Ye Qing, Deng Jie, Ji Fan-Pu, Li Xian-Lun, Wang Qian, Yang Song, Zhao Jingjing, Yang Hui, Hou Fang-Jie, Xin Yong-Ning, He You-Fu, Luo Xin-Hua, Gao Yu-Feng, Guan Hao, Wang Qi, Ye Zhong, Zheng Yu-Bao, Deqing Bai-Zhen, Zhang Li-Ting, Ma Zhen-Qi, Zhang Cheng-Long, Huang Yan, Peng Xiao-Ping, Wu Xiao-Ping, Xiang Rui, Deng Liang, Shalaimaiti Shali, Xia Ming-Feng, Zhao Yang, Miao Xiao-Fan, Sun Xin-Yi, Yu Ge, Man Yi-Long, Zhou Ruo-Qi, Zhang Hao-Tian, Tang Jia-Ke, Feng Cheng-Cheng, Zhang Shuai-Ran, Hu Yue-Yan, Jiang Shu-Jun, Li Jia, Su Guan-Yue, Ye Jun-Zhao, Qian Bao-Xin, Liang Xiao, Ren Yuan-Yuan, Li Yan, Zhang Xiao-Qian, Geng Ning, Peng Hong, Tuerxun Kebinuer, Liu Li-Gai, He Chun-Yi, Li Jun-Feng, Zhang Hong-Yan, Yang Li-Xia, Lu Zheng-Jie, Chai Jin, Hong Cheng-Lv, Zheng Ming-Hua, CHAIN Consortium

Протокол клинического исследованияСтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

Metabolic dysfunction-associated steatotic liver disease (MASLD) is highly prevalent among patients with cardiovascular disease but remains underrecognized in routine cardiology practice. To address the limited prospective evidence on its progression and clinical impact, we established the CHAIN cohort, a prospective multicenter study enrolling approximately 15 000 adults undergoing coronary evaluation across 40 tertiary hospitals in China. Baseline assessment includes comprehensive cardiometabolic profiling and vibration-controlled transient elastography for evaluation of liver fibrosis and steatosis. Participants will undergo long-term follow-up with repeated liver assessments every 6-12 months. Primary outcomes include liver-related events and major adverse cardiovascular events, while secondary outcomes include longitudinal changes in liver fibrosis and steatosis and their associations with cardiometabolic risk factors and clinical outcomes. This cohort will provide longitudinal evidence to support risk stratification and integrated heart-liver management in cardiovascular care.

Для цитирования: Zhou Xiao-Dong, Fan Ren Cheng-Han, Chen Jian-Dong, Zhou Xi-Qiao, Tong Qian, Gao Yan-Hang, Wang Xiao-Qi, Jiang Ya-Kun, Pu Xiang-Yuan, Shi Yu, Wang Ming-Wei, Liu Jing, Jiang Hai-Bing, Ma Li, Zhang Xin-Gang, Li Yi-Ling, Lin Su, Yang Hong-Ju, Song Yao-Hong, Zhang Yan-Liang, Lu Cheng-Zhi, Wang Feng-Mei, Shen De-Liang, Liang Hong-Xia, Luo Qiang, Chen En-Qiang, Li Bo, Zhong Bi-Hui, Liu Ying-Wu, Ye Qing, Deng Jie, Ji Fan-Pu, Li Xian-Lun, Wang Qian, Yang Song, Zhao Jingjing, Yang Hui, Hou Fang-Jie, Xin Yong-Ning, He You-Fu, Luo Xin-Hua, Gao Yu-Feng, Guan Hao, Wang Qi, Ye Zhong, Zheng Yu-Bao, Deqing Bai-Zhen, Zhang Li-Ting, Ma Zhen-Qi, Zhang Cheng-Long, Huang Yan, Peng Xiao-Ping, Wu Xiao-Ping, Xiang Rui, Deng Liang, Shalaimaiti Shali, Xia Ming-Feng, Zhao Yang, Miao Xiao-Fan, Sun Xin-Yi, Yu Ge, Man Yi-Long, Zhou Ruo-Qi, Zhang Hao-Tian, Tang Jia-Ke, Feng Cheng-Cheng, Zhang Shuai-Ran, Hu Yue-Yan, Jiang Shu-Jun, Li Jia, Su Guan-Yue, Ye Jun-Zhao, Qian Bao-Xin, Liang Xiao, Ren Yuan-Yuan, Li Yan, Zhang Xiao-Qian, Geng Ning, Peng Hong, Tuerxun Kebinuer, Liu Li-Gai, He Chun-Yi, Li Jun-Feng, Zhang Hong-Yan, Yang Li-Xia, Lu Zheng-Jie, Chai Jin, Hong Cheng-Lv, Zheng Ming-Hua, CHAIN Consortium. CHAIN Cohort: Prospective Multicenter Study of MASLD With Serial Liver Stiffness Assessments in Cardiovascular Care.. Liver international : official journal of the International Association for the Study of the Liver. 2026. DOI: 10.1111/liv.70805.

Предметные рубрики MeSH

Adult Female Humans Male Cardiovascular Diseases China Elasticity Imaging Techniques Fatty Liver Liver Liver Cirrhosis Prospective Studies Risk Factors Multicenter Studies as Topic Observational Studies as Topic

Подготовка и перевод публикации

Обработка статьи · этапы, ошибки и управление

Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.

Тип публикации указан по данным источника. Уровень доказательности автоматически не присваивается.

Аннотация

Предметные рубрики MeSH

Ошибки и ограничения