Longitudinal association of dietary spermidine with hepatic function indexes and cardiometabolic traits in older adults with metabolic syndrome.
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López-González Andrés, Cuadrado-Soto Esther, Ordovás José M, Martínez-González Miguel Ángel, Corella Dolores, Salas-Salvadó Jordi, Fitó Montserrat, Martínez J Alfredo, Alonso-Gómez Ángel M, Wärnberg Julia, Vioque Jesús, Romaguera Dora, López-Miranda José, Estruch Ramon, Tinahones Francisco J, Lapetra José, Serra-Majem J Lluís, Bueno-Cavanillas Aurora, Tur Josep A, Sánchez Vicente Martín, Pintó Xavier, Delgado-Rodríguez Miguel, Matía-Martín Pilar, Vidal Josep, Vázquez Clotilde, Cofán Montserrat, Basterra-Gortari Javier, Fernandez-Carrion Rebeca, Babio Nancy, Niño Olga Castañer, Martínez-Urbistondo Diego, Tojal-Sierra Lucas, Fernández-Barceló Olga, Ojeda-Belokon Carolina, Konieczna Jadwiga, Arenas-Larriva Antonio Pablo, Casas Rosa Mª, Mr Bernal-López, Martín-Peláez Sandra, Ruiz-Canela Miguel, Ortega-Azorin Carolina, Plaza-Diaz Julio, Pérez-Vega Karla Alejandra, Zulet María Ángeles, Salaverria-Lete Itziar, González-Palacios Sandra, Vazquez-Ruiz Zenaida, Pérez-Acosta Josué A, Pascual Víctor de la O, Daimiel Lidia
Аннотация
METHODS: We used baseline and 1-year follow-up data from 2664 participants from the PREDIMED-Plus trial. Dietary spermidine intake was estimated using a semi-quantitative food frequency questionnaire. Time series clustering identified temporal patterns of 1-year change in spermidine intake. Linear mixed-effects models assessed the associations between spermidine intake clusters and changes in hepatic and cardiometabolic markers.
RESULTS: Three distinct spermidine intake patterns were identified across baseline, six months and 1 year follow-up. Cluster 3, characterized by the highest baseline and increased 1-year spermidine intake, was associated with mean reductions in fatty liver index (- 8.97 [- 9.96 to - 7.97], p-int < 0.001), hepatic steatosis index (- 1.88 [- 2.13 to - 1.63], p-int < 0.001), alanine aminotransferase (- 2.93 [- 3.83 to - 2.02] U/L, p-int < 0.05), aspartate aminotransferase (- 1.11 [- 1.76 to - 0.45] U/L, p-int < 0.05) and glycated hemoglobin levels (- 0.14 [- 0.18 to - 0.10]%, p-int < 0.01). Cluster 3 also showed, mean decreases in body mass index (- 1.26 [- 1.37 to - 1.15]), waist (- 3.72 [- 4.11 to - 3.32] cm) and hip circumference (- 2.33 [- 2.67 to - 1.99] cm) (all p-int < 0.001).
CONCLUSION: A 1-year increase in dietary spermidine intake was associated with improvements in hepatic function indexes and cardiometabolic traits in overweight and obese older adults with metabolic syndrome.