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DOI 10.1080/09273948.2020.1774905

Медицинская библиотека · Ocular immunology and inflammation · 2020

Visual Morbidity in Ocular Tuberculosis - Collaborative Ocular Tuberculosis Study (COTS)-1: Report #6.

Agrawal Rupesh, Gunasekeran Dinesh Visva, Agarwal Aniruddha, Testi Ilaria, Carreño Ester, Westcott Mark, Mahajan Sarakshi, Raje Dhananjay, Aggarwal Kanika, Murthy Somasheila I, Chee Soon-Phaik, Mccluskey Peter, Ho Su Ling, Teoh Stephen, Cimino Luca, Biswas Jyotirmay, Narain Shishir, Agarwal Manisha, Mahendradas Padmamalini, Khairallah Moncef, Jones Nicholas, Tugal-Tutkun Ilknur, Babu Kalpana, Basu Soumayava, Lee Richard, Al-Dhibi Hassan, Bodaghi Bahram, Invernizzi Alessandro, Goldstein Debra A, Herbort Carl P, Barisani-Asenbauer Talin, González-López Julio J, Androudi Sofia, Bansal Reema, Moharana Bruttendu, Esposti Simona Degli, Tasiopoulou Anastasia, Nadarajah Sengal, Agarwal Mamta, Abraham Sharanaya, Vala Ruchi, Singh Ramandeep, Sharma Aman, Sharma Kusum, Zierhut Manfred, Kon Onn Min, Cunningham Emmett T, Kempen John H, Nguyen Quan Dong, Pavesio Carlos, Gupta Vishali

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Аннотация

Objective

Aim of the study was to examine extent, natural history, and clinical features associated with visual impairment (VI) in patients diagnosed with ocular tuberculosis (OTB) by the Collaborative Ocular Tuberculosis Study (COTS)-1.

Methods

Multi-center retrospective cohort study. Main outcomes were VI.

Results

A total of 302 patients were included in the study, including 175 patients whose data related to BCVA were available throughout the 2 years of follow up. Mean BCVA grossly improved at 12, 18, and 24 months of follow-up (p < .001). Mean BCVA was worse at 12-18th month follow-up for patients treated with ATT versus patients who were not treated with ATT, but patients treated with ATT had a statistically significant improvement in BCVA at the 24-month endpoint.

Conclusions

OTB is associated with significant visual morbidity, future well-designed prospective studies are warranted to establish the causal association between OTB and visual loss.

Для цитирования: Agrawal Rupesh, Gunasekeran Dinesh Visva, Agarwal Aniruddha, Testi Ilaria, Carreño Ester, Westcott Mark, Mahajan Sarakshi, Raje Dhananjay, Aggarwal Kanika, Murthy Somasheila I, Chee Soon-Phaik, Mccluskey Peter, Ho Su Ling, Teoh Stephen, Cimino Luca, Biswas Jyotirmay, Narain Shishir, Agarwal Manisha, Mahendradas Padmamalini, Khairallah Moncef, Jones Nicholas, Tugal-Tutkun Ilknur, Babu Kalpana, Basu Soumayava, Lee Richard, Al-Dhibi Hassan, Bodaghi Bahram, Invernizzi Alessandro, Goldstein Debra A, Herbort Carl P, Barisani-Asenbauer Talin, González-López Julio J, Androudi Sofia, Bansal Reema, Moharana Bruttendu, Esposti Simona Degli, Tasiopoulou Anastasia, Nadarajah Sengal, Agarwal Mamta, Abraham Sharanaya, Vala Ruchi, Singh Ramandeep, Sharma Aman, Sharma Kusum, Zierhut Manfred, Kon Onn Min, Cunningham Emmett T, Kempen John H, Nguyen Quan Dong, Pavesio Carlos, Gupta Vishali. Visual Morbidity in Ocular Tuberculosis - Collaborative Ocular Tuberculosis Study (COTS)-1: Report #6.. Ocular immunology and inflammation. 2020. DOI: 10.1080/09273948.2020.1774905.
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