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DOI 10.1080/09273948.2020.1761400

Медицинская библиотека · Ocular immunology and inflammation · 2020

The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Review of 165 Patients with Tubercular Anterior Uveitis.

Agrawal Rupesh, Betzler Bjorn, Testi Ilaria, Mahajan Sarakshi, Agarwal Aniruddha, Gunasekeran Dinesh Visva, Raje Dhananjay, Aggarwal Kanika, Murthy Somasheila I, Westcott Mark, Chee Soon-Phaik, Mccluskey Peter, Ho Su Ling, Teoh Stephen, Cimino Luca, Biswas Jyotirmay, Narain Shishir, Agarwal Manisha, Mahendradas Padmamalini, Khairallah Moncef, Jones Nicholas, Tugal-Tutkun Ilknur, Babu Kalpana, Basu Soumayava, Carreño Ester, Lee Richard, Al-Dhibi Hassan, Bodaghi Bahram, Invernizzi Alessandro, Goldstein Debra A, Herbort Carl P, Barisani-Asenbauer Talin, González-López Julio J, Androudi Sofia, Bansal Reema, Moharana Bruttendu, Esposti Simona, Tasiopoulou Anastasia, Nadarajah Sengal, Agarwal Mamta, Abraham Sharanya, Vala Ruchi, Singh Ramandeep, Sharma Aman, Sharma Kusum, Zierhut Manfred, Kon Onn Min, Cunningham Emmett T, Kempen John H, Nguyen Quan Dong, Pavesio Carlos, Gupta Vishali

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Аннотация

Purpose: The Collaborative Ocular Tuberculosis Study (COTS) Group sought to address the diagnostic uncertainty through retrospective cohort analysis of treatment regimens and therapeutic outcomes for patients with tubercular Anterior Uveitis (TAU) across international centers.

Methods

Multicentre retrospective analysis of patients diagnosed with TAU between January 2004 to December 2014 that had a minimum follow-up of 1 year.

Results

One hundred and sixty-five patients were included. One hundred and seven subjects received antitubercular therapy (ATT) (n = 107/165; 64.9%) with all the patients receiving topical steroid therapy. Treatment failure was noted in 17 patients (n = 17/165; 10.3%), more frequently described in patients that received ATT (n = 13/107, 12.2%), than those that did not receive ATT (n = 4/58, 6.9%).

Conclusion

In this retrospective study, addition of ATT did not have any statistically significant impact on outcome in patients with TAU.

Для цитирования: Agrawal Rupesh, Betzler Bjorn, Testi Ilaria, Mahajan Sarakshi, Agarwal Aniruddha, Gunasekeran Dinesh Visva, Raje Dhananjay, Aggarwal Kanika, Murthy Somasheila I, Westcott Mark, Chee Soon-Phaik, Mccluskey Peter, Ho Su Ling, Teoh Stephen, Cimino Luca, Biswas Jyotirmay, Narain Shishir, Agarwal Manisha, Mahendradas Padmamalini, Khairallah Moncef, Jones Nicholas, Tugal-Tutkun Ilknur, Babu Kalpana, Basu Soumayava, Carreño Ester, Lee Richard, Al-Dhibi Hassan, Bodaghi Bahram, Invernizzi Alessandro, Goldstein Debra A, Herbort Carl P, Barisani-Asenbauer Talin, González-López Julio J, Androudi Sofia, Bansal Reema, Moharana Bruttendu, Esposti Simona, Tasiopoulou Anastasia, Nadarajah Sengal, Agarwal Mamta, Abraham Sharanya, Vala Ruchi, Singh Ramandeep, Sharma Aman, Sharma Kusum, Zierhut Manfred, Kon Onn Min, Cunningham Emmett T, Kempen John H, Nguyen Quan Dong, Pavesio Carlos, Gupta Vishali. The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Review of 165 Patients with Tubercular Anterior Uveitis.. Ocular immunology and inflammation. 2020. DOI: 10.1080/09273948.2020.1761400.
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