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Journal of the American Academy of Dermatology · 2026

A new perspective on the treatment and management of atypical nevi: A blinded retrospective analysis of atypical nevi utilizing line-field confocal optical coherence tomography.

СтатьяНазвание и аннотация: Перевод в очереди
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Ong Sherry, Markowitz Orit

Аннотация

BACKGROUND: Limitations exist among current noninvasive imaging techniques for evaluating equivocal melanocytic lesions. Line-field confocal optical coherence tomography was introduced to bridge the gap between these technologies.

OBJECTIVE: To further establish this device as a useful imaging modality and refine the current criteria for differentiating between benign and malignant lesions.

METHODS: Seventy-five lesions were included in this study, and each was subjected to a biopsy, short-term mole monitoring, or DermTech Melanoma Test. The existing criteria for line-field confocal optical coherence tomography were analyzed retrospectively.

RESULTS: The statistically significant criteria for distinguishing between benign vs malignant lesions include the presence of atypical honeycomb, dendritic cells with moderate or severe levels of pleomorphism, and clefting.

LIMITATIONS: This study has a limited sample size and was conducted at a single center.

CONCLUSION: We have identified diagnostic criteria that can be useful in analyzing equivocal melanocytic lesions.

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