Modeling Time to Death of Patients with Multidrug-Resistant Tuberculosis at Saint Peter's Specialized Hospital.

UNLABELLED: Whipple's disease is a rare, chronic systemic infection caused by Tropheryma whipplei that commonly presents with gastrointestinal manifestations but may involve multiple extraintestinal organs. Cardiac involvement, particularly culture-negative endocarditis, is described; however, pulmonary complications such as pulmonary hypertension (PH) are uncommon. We report a case of Whipple's disease presenting with severe pre-capillary pulmonary hypertension and right ventricular (RV) failure with reversibility following antimicrobial therapy. A 62-year-old woman with seropositive rheumatoid arthritis on adalimumab, presented with one month of profuse watery diarrhoea, abdominal pain, dizziness and weakness. Imaging revealed diffuse mesenteric and para-aortic lymphadenopathy. Upper endoscopy demonstrated oedematous whitish granular villi in the duodenum, and biopsies showed periodic acid-Schiff-positive, acid-fast bacillus-negative foamy macrophages diagnostic of Whipple's disease. Transthoracic echocardiography revealed RV dilation and dysfunction with pulmonary hypertension, which was confirmed on right heart catheterisation as severe pre-capillary PH with elevated pulmonary vascular resistance and normal wedge pressure. The patient developed RV-predominant cardiogenic shock requiring inotropic and vasopressor support. Following initiation of intravenous ceftriaxone her haemodynamics improved rapidly, with normalisation of cardiac output and marked reduction in pulmonary pressures on repeat catheterisation. Gastrointestinal symptoms resolved, immunosuppressive therapy was discontinued, and she was discharged on prolonged antimicrobial therapy. This case underscores PH as a rare but potentially reversible manifestation of Whipple's disease. Recognition of this entity is critical, as PH-specific vasodilator therapy alone is often ineffective, whereas early targeted antimicrobial treatment can result in rapid and profound clinical and haemodynamic recovery, even in cases presenting with severe RV failure.

LEARNING POINTS: Whipple's disease should be considered in the differential diagnosis of otherwise unexplained pre-capillary pulmonary hypertension, particularly when accompanied by chronic diarrhoea, arthralgia or systemic features.Unlike idiopathic pulmonary arterial hypertension, Whipple's disease-associated pulmonary hypertension is often driven by a reversible inflammatory process and may present with severe right ventricular failure and haemodynamic compromise.Recognition of this rare entity is critical, as pulmonary hypertension-specific vasodilator therapy alone is frequently insufficient, whereas timely initiation of targeted antimicrobial treatment can result in rapid and profound clinical and haemodynamic recovery.