Quintessence international (Berlin, Germany : 1985) · 2026
Effects of hyaluronic acid as an adjunct to nonsurgical treatment of periodontal pockets: a narrative review.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Mauriello Leopoldo, Pezzella Vitolante, Blasi Andrea, Lanzillo Sossio-Giuseppe, Iorio-Siciliano Vincenzo, Ramaglia Luca
Аннотация
OBJECTIVE: Periodontitis is a chronic inflammatory condition characterized by clinical attachment loss, periodontal pockets, bleeding on probing, gingival recession, and alveolar bone loss. Nonsurgical periodontal therapy (NSPT) is effective in the periodontal pocket reduction; however, a proportion of residual pockets can be assessed after completion of NSPT. Hyaluronic acid, due to its anti-inflammatory and regenerative properties, has been proposed as a topical adjunct to enhance NSPT outcomes. This review aimed to summarize and evaluate the current evidence on the adjunctive use of hyaluronic acid in NSPT.
METHOD AND MATERIALS: An electronic and hand literature search was conducted across MEDLINE, Embase, and Web of Science for clinical studies published in English up to 2024. Randomized controlled trials, retrospective studies, and case series evaluating the adjunctive application of hyaluronic acid in NSPT were included.
RESULTS: Eight clinical studies published between 2013 and 2024 were selected. Most studies showed that the adjunctive use of hyaluronic acid significantly improved probing depth reduction, clinical attachment level gain, and the percentage of pocket closure compared with NSPT alone. The combination of sodium hypochlorite/amino acid gel with cross-linked hyaluronic acid showed the greatest clinical benefits. No study reported adverse events associated with hyaluronic acid use.
CONCLUSIONS: Considering the analyzed data, the use of hyaluronic acid, cross-linked formulations in particular, seems to be effective as adjunct to NSPT. Furthermore, the combined application of sodium hypochlorite/amino acids and cross-linked hyaluronic acid appears to enhance clinical outcomes. (Quintessence Int 2026;57:6-14; doi: 10.3290/j.qi.b6689073).
METHOD AND MATERIALS: An electronic and hand literature search was conducted across MEDLINE, Embase, and Web of Science for clinical studies published in English up to 2024. Randomized controlled trials, retrospective studies, and case series evaluating the adjunctive application of hyaluronic acid in NSPT were included.
RESULTS: Eight clinical studies published between 2013 and 2024 were selected. Most studies showed that the adjunctive use of hyaluronic acid significantly improved probing depth reduction, clinical attachment level gain, and the percentage of pocket closure compared with NSPT alone. The combination of sodium hypochlorite/amino acid gel with cross-linked hyaluronic acid showed the greatest clinical benefits. No study reported adverse events associated with hyaluronic acid use.
CONCLUSIONS: Considering the analyzed data, the use of hyaluronic acid, cross-linked formulations in particular, seems to be effective as adjunct to NSPT. Furthermore, the combined application of sodium hypochlorite/amino acids and cross-linked hyaluronic acid appears to enhance clinical outcomes. (Quintessence Int 2026;57:6-14; doi: 10.3290/j.qi.b6689073).