The Journal of surgical research · 2026
Extending the Observational Medical Outcomes Partnership Common Data Model to Support Observational Peripheral Vascular Disease Research.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Leese Peter J, McIntee Tomas, Browder Sydney E, Laivuori Mirjami, Alabi Olamide, McGinigle Katharine L
Аннотация
INTRODUCTION: Peripheral artery disease (PAD) and chronic limb-threatening ischemia (CLTI) cause substantial morbidity and mortality, yet research progress is limited by fragmented, nonstandardized data. The Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM) provides a standardized framework for electronic health record research but lacks domain-specific detail for peripheral vascular diseases. This study aimed to develop and test a vascular-specific OMOP CDM extension to improve data standardization, enable reproducible real-world analyses, and support precision medicine research in PAD and CLTI.
METHODS: We identified patients with PAD, CLTI, or diabetic foot ulcers who sought care within the University of North Carolina Health System between April 2014 and July 2024. Standard OMOP tables were supplemented with peripheral vascular laboratory data and North Carolina state death certificate records. Intermediate tables were designed for key clinical domains (e.g., smoking, comorbidities, revascularizations) to enhance reusability. Predictive models for revascularization and mortality were developed using logistic regression with Bayesian weighting and Markov Chain Monte Carlo feature selection.
RESULTS: The revascularization model displayed high performance with and without important vascular variables (area under the curve [AUC] = 0.970 and AUC 0.969, respectively), while the mortality model demonstrated moderate accuracy (AUC = 0.656) that improved with inclusion of vascular-specific features (AUC = 0.752).
CONCLUSIONS: This vascular OMOP extension represents one of the first specialty-specific frameworks for peripheral vascular research. By extending the OMOP CDM to a vascular domain, this work advances both the technical framework and scientific capability of real-world data research in limb preservation and precision vascular medicine.
METHODS: We identified patients with PAD, CLTI, or diabetic foot ulcers who sought care within the University of North Carolina Health System between April 2014 and July 2024. Standard OMOP tables were supplemented with peripheral vascular laboratory data and North Carolina state death certificate records. Intermediate tables were designed for key clinical domains (e.g., smoking, comorbidities, revascularizations) to enhance reusability. Predictive models for revascularization and mortality were developed using logistic regression with Bayesian weighting and Markov Chain Monte Carlo feature selection.
RESULTS: The revascularization model displayed high performance with and without important vascular variables (area under the curve [AUC] = 0.970 and AUC 0.969, respectively), while the mortality model demonstrated moderate accuracy (AUC = 0.656) that improved with inclusion of vascular-specific features (AUC = 0.752).
CONCLUSIONS: This vascular OMOP extension represents one of the first specialty-specific frameworks for peripheral vascular research. By extending the OMOP CDM to a vascular domain, this work advances both the technical framework and scientific capability of real-world data research in limb preservation and precision vascular medicine.