A PROTECTIVE ROLE FOR MAGNESIUM 2-AMINOETHANSULFONATE IN PARACETAMOL AND ETHANOL-INDUCED LIVER INJURY IN PREGNANT RATS.

UNLABELLED: The goal: to investigate a preventive activity for novel medication magnesium 2-aminoethansulfonate in experimental hepatitis in pregnant rats.

MATERIAL AND

METHODS

The study has been conducted in firs week pregnant rats with paracetamol and ethanol-induced liver injury.

RESULTS

There has been found out that new domestic compound magnesium 2-aminoethansulfonate (laboratory name LBK-527) introduced daily at a dose of 28 mg/kg per os during 6 days, limits cytolysis and cholestasis caused by either paracetamol or ethanol intake in experiments in pregnant rats. Study shows that liver of the animals, that have been given LBK-527 simultaneously with either 500 mg/kg paracetamol or 10 ml/kg 40% ethanol, remains being structurally close to normal. The substance prevents acute toxic liver dystrophy and the organ's structure disintegration made by mentioned toxic agents. Having administered at a therapeutic dose LBK-527 isn't associated with faetotoxicity and embriototoxity in experiments in rats.