Retinal involvement of Paracoccioidomycosis: A Case Report.

PURPOSE: to describe the clinicopathologic features and treatment of a rare case of systemic paracoccidioidomycosis with choroidal and retinal involvement.

DESIGN

retrospective interventional case report.

PARTICIPANT: A 36-year-old young man with visual impairment in left eye with anterior uveitis and presence of whitish perimacular choroidal nodule, multiple underlying whitish spots and mid-periphery exudative retinal detachment. A primary extensive work-up for systemic infectious, autoimmune, neoplasic or inflammatory conditions was performed and high-resolution computer tomography scan demonstrated asymmetric parietal thickening of the trachea and bilateral diffuse multiple lobular opacities. Pulmonary bronchoscopy/biopsy of larynx, trachea and bronchial tube were also performed. Histopathological evaluation showed characteristic of Paracoccidioidomycosis.

INTERVENTION: Patient was treated with oral sulphadiazine (1.5 g/day).

MAIN OUTCOME MEASURES: Anterior uveitis, retinal examination, histopathological evaluation and primary clinical outcome were observed during systemic treatment.

RESULTS

After 3 months of irregular treatment, choroidal lesions decreased in size forming atrophic scars and fibrotic spots; however visual acuity did not show any improvement.

CONCLUSION

We report a rare case of systemic paracoccidioidomycosis with choroidal and retinal involvement treated with oral sulphadiazine.