Ocular immunology and inflammation · 2014
Polymerase chain reaction evaluation of infectious multifocal serpiginoid choroiditis.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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Mohan Neha, Balne Praveen Kumar, Panda Krushna Gopal, Sharma Savitri, Basu Soumyava
Аннотация
PURPOSE: To study infectious agents associated with multifocal serpiginoid choroiditis (MSC) based on polymerase chain reaction (PCR) evaluation and specific anti-microbial therapy.
METHODS: Retrospective review of medical records.
RESULTS: Thirteen patients with MSC were evaluated with PCR for the following organisms: Mycobacterium tuberculosis (MTB), herpes simplex virus 1 (HSV 1), varicella zoster virus (VZV), and cytomegalovirus (CMV). Nine (69.2%) were PCR positive for one or more organisms. Seven (53.8%) were positive for MTB, 3 (23.1%) for CMV (1 positive for both MTB and CMV), and 1 (7.6%) for both HSV 1 and MTB. All 13 patients received anti-TB therapy and corticosteroids. Nine patients completed 6 months follow-up; 6 resolved completely, 2 continued to have active lesions, while 1 CMV PCR-positive patient required additional valgancyclovir therapy.
CONCLUSIONS: TB is the most important etiology for MSC in endemic countries. The role of herpes viruses in MSC remains unclear and needs further investigation.
METHODS: Retrospective review of medical records.
RESULTS: Thirteen patients with MSC were evaluated with PCR for the following organisms: Mycobacterium tuberculosis (MTB), herpes simplex virus 1 (HSV 1), varicella zoster virus (VZV), and cytomegalovirus (CMV). Nine (69.2%) were PCR positive for one or more organisms. Seven (53.8%) were positive for MTB, 3 (23.1%) for CMV (1 positive for both MTB and CMV), and 1 (7.6%) for both HSV 1 and MTB. All 13 patients received anti-TB therapy and corticosteroids. Nine patients completed 6 months follow-up; 6 resolved completely, 2 continued to have active lesions, while 1 CMV PCR-positive patient required additional valgancyclovir therapy.
CONCLUSIONS: TB is the most important etiology for MSC in endemic countries. The role of herpes viruses in MSC remains unclear and needs further investigation.
Предметные рубрики MeSH
AdultAqueous HumorChoroiditisDNA, BacterialDNA, ViralDiagnosis, DifferentialEye Infections, BacterialEye Infections, ViralFemaleFluorescein AngiographyFollow-Up StudiesFundus OculiHumansMaleMiddle AgedMultifocal ChoroiditisPolymerase Chain ReactionReproducibility of ResultsRetrospective StudiesTime FactorsYoung Adult