Nutrition & metabolism · 2026
Characterization of avocado seeds aqueous extract and its therapeutic effects on gastric ulcer.
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Sultan Aroosa, Akhtar Muhammad Nadeem, Khalil Anees Ahmed, Jameel Faiza, Ballal Suhas, Singh Abhayveer, Panigrahi Rajashree, Sharma Abhishek, Ateeq Huda, Ahmed Areesha, Islam Fakhar, Afzaal Muhammad, Ndagire Catherine Tamale
Аннотация
BACKGROUND: Helicobacter pylori infection and oxidative stress are most common factors for development of gastric ulcers which is consider to be a most common gastrointestinal disorder. The main objective of this research was to evaluate the effects of avocado seeds aqueous extract as an adjunct to conventional ulcer treatment.
METHODS: A randomized controlled trial was conducted with the participation of 99 patients diagnosed with gastric ulcers. Participants were randomly divided to a control group receiving standard medication and interventional group receiving the same treatment with avocado seeds aqueous extract. Screening and follow-up assessments assessment was performed by barium meal tests, radiological imaging, and serological markers, including H. pylori IgG and IgM (ELISA).
RESULTS: Patients in the intervention group showed significant improvements in ulcer morphology and a marked reduction in H. pylori IgG and IgM levels compared with the control group (p < 0.05). Radiological findings also confirmed better mucosal healing in the supplemented group after 12 weeks of intervention.
CONCLUSIONS: Intervention group with avocado seeds aqueous extract showed a positive effect combined with conventional treatment, suggesting its potential as a natural adjunct therapy in management of gastric ulcers.
METHODS: A randomized controlled trial was conducted with the participation of 99 patients diagnosed with gastric ulcers. Participants were randomly divided to a control group receiving standard medication and interventional group receiving the same treatment with avocado seeds aqueous extract. Screening and follow-up assessments assessment was performed by barium meal tests, radiological imaging, and serological markers, including H. pylori IgG and IgM (ELISA).
RESULTS: Patients in the intervention group showed significant improvements in ulcer morphology and a marked reduction in H. pylori IgG and IgM levels compared with the control group (p < 0.05). Radiological findings also confirmed better mucosal healing in the supplemented group after 12 weeks of intervention.
CONCLUSIONS: Intervention group with avocado seeds aqueous extract showed a positive effect combined with conventional treatment, suggesting its potential as a natural adjunct therapy in management of gastric ulcers.