The Journal of nutrition · 2026
Postprandial Vitamin E Plasma Enrichment and Second Meal Effect in Women with and without Metabolic Dysfunction-Associated Steatotic Liver Disease.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Violet Pierre-Christian, Greene Thom, Teng Stephanie, Wang Yu, Leonard Scott W, Head Brian, Wright Elizabeth C, Shamburek Robert, Traber Maret G, Levine Mark, Ebenuwa Ifechukwude
Аннотация
BACKGROUND: The effect of meal fat sequence and excess body fat on postprandial changes in vitamin E absorption is unclear.
OBJECTIVES: We investigated postprandial changes in plasma vitamin E enrichment in response to varied dietary fat sequences in healthy women and excess body and liver fat in women with obesity and metabolic dysfunction-associated steatotic liver disease (MASLD).
METHODS: Vitamin E [α-tocopherol (α-T)] pharmacokinetics were assessed using deuterium (d)-labeled α-T administered orally [d3-RRR-α-tocopherol (d3-α-T)] and intravenously [d6-RRR-α-tocopherol (d6-α-T)]. A total of 13 healthy women received oral and intravenous (IV) α-T (30 mg) with a liquid breakfast containing 40% or 0% fat, followed by 30% fat lunch and dinner at 4 h and 8 h, or a 12-h fast (0% fat-fast). A total of 6 women with MASLD and 10 normal weight controls received oral and IV α-T (2 mg) with similar meal sequence. Major outcomes were postprandial plasma α-T %enrichment, maximal concentration (Cmax), and area under the curves (AUCs) at 4, 12, and 24 h. Exploratory outcomes included the second meal effect (SME), defined as mean change in pre-2nd meal compared with post-2nd meal d3-α-T %enrichment at 4 h and 12 h, respectively.
RESULTS: At 4-h oral d3-α-T %enrichment, Cmax and AUC0-4 h were not statistically different between 40% and 0% fat groups. Following the 2nd meal at 4 h, SME was 55% higher in the 0% group than in the 40% group (15.8% ± 1.1% compared with 10.2% ± 1.1%, P < 0.009), resulting in greater Cmax and AUC in the 0% group at 12 and 24 h (P < 0.04). Compared with the 0% group, the 0% fat-fast group showed reduced oral d3-α-T %enrichment, whereas no differences were seen with IV d6-α-T %enrichments. Compared with controls, the obese/MASLD cohort had 31% lower SME (0.87% ± 0.1% compared with 1.26% ± 0.1%, P = 0.047), resulting in reduced Cmax and AUC (P < 0.04) at 24 h.
CONCLUSIONS: The variation in the meal fat sequence (0%-30% compared with 40%-30% fat) significantly enhanced SME and postprandial d3-α-T %enrichment, whereas obesity/MASLD attenuated SME and postprandial vitamin E %enrichment.
OBJECTIVES: We investigated postprandial changes in plasma vitamin E enrichment in response to varied dietary fat sequences in healthy women and excess body and liver fat in women with obesity and metabolic dysfunction-associated steatotic liver disease (MASLD).
METHODS: Vitamin E [α-tocopherol (α-T)] pharmacokinetics were assessed using deuterium (d)-labeled α-T administered orally [d3-RRR-α-tocopherol (d3-α-T)] and intravenously [d6-RRR-α-tocopherol (d6-α-T)]. A total of 13 healthy women received oral and intravenous (IV) α-T (30 mg) with a liquid breakfast containing 40% or 0% fat, followed by 30% fat lunch and dinner at 4 h and 8 h, or a 12-h fast (0% fat-fast). A total of 6 women with MASLD and 10 normal weight controls received oral and IV α-T (2 mg) with similar meal sequence. Major outcomes were postprandial plasma α-T %enrichment, maximal concentration (Cmax), and area under the curves (AUCs) at 4, 12, and 24 h. Exploratory outcomes included the second meal effect (SME), defined as mean change in pre-2nd meal compared with post-2nd meal d3-α-T %enrichment at 4 h and 12 h, respectively.
RESULTS: At 4-h oral d3-α-T %enrichment, Cmax and AUC0-4 h were not statistically different between 40% and 0% fat groups. Following the 2nd meal at 4 h, SME was 55% higher in the 0% group than in the 40% group (15.8% ± 1.1% compared with 10.2% ± 1.1%, P < 0.009), resulting in greater Cmax and AUC in the 0% group at 12 and 24 h (P < 0.04). Compared with the 0% group, the 0% fat-fast group showed reduced oral d3-α-T %enrichment, whereas no differences were seen with IV d6-α-T %enrichments. Compared with controls, the obese/MASLD cohort had 31% lower SME (0.87% ± 0.1% compared with 1.26% ± 0.1%, P = 0.047), resulting in reduced Cmax and AUC (P < 0.04) at 24 h.
CONCLUSIONS: The variation in the meal fat sequence (0%-30% compared with 40%-30% fat) significantly enhanced SME and postprandial d3-α-T %enrichment, whereas obesity/MASLD attenuated SME and postprandial vitamin E %enrichment.