Sleep medicine · 2025
Longitudinal ultrasound assessment of vagus nerve morphology in isolated REM sleep behavior disorder and Parkinson's disease.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Miyamoto Tomoyuki, Inagaki Masaki, Okuma Chihiro, Akaiwa Yasuhisa, Sairenchi Toshimi, Miyamoto Masayuki
Аннотация
INTRODUCTION: Ultrasonography has shown that the vagus nerve cross-sectional area (VN-CSA) is reduced in patients with Parkinson's disease (PD). However, the status of the VN in prodromal PD is unclear. The objectives of this study were to assess: 1) the VN-CSA in healthy control subjects versus patients with isolated rapid eye movement sleep behavior disorder (IRBD) or PD; 2) the laterality of VN size; 3) whether the VN-CSA changes over time; and 4) whether the VN-CSA can serve as an indicator of the progression of neurodegeneration in IRBD or PD.
METHODS: We performed ultrasonography to determine the right and left VN-CSA in 57 Japanese patients with IRBD, 41 patients with PD, and 27 controls. VN-CSA was followed up for 3 months or more after the baseline examination in 21 of the IRBD patients and 14 of the PD patients.
RESULTS: There were no significant differences in the mean right or left VN-CSA between the three groups. The mean left VN-CSA was significantly reduced in IRBD after a mean follow-up period of 2.3 ± 0.9 years (P = 0.0069). In the PD group, a negative correlation between motor function (assessed by the MDS-UPDRS part III) and the VN-CSA.
CONCLUSIONS: Repeatedly monitoring the left VN-CSA might serve as an indicator of IRBD progression. The VN-CSA may be further reduced in PD compared with IRBD. These data comparing changes in the VN-CSA over time in patients with IRBD and early PD provide a starting point for future research.
METHODS: We performed ultrasonography to determine the right and left VN-CSA in 57 Japanese patients with IRBD, 41 patients with PD, and 27 controls. VN-CSA was followed up for 3 months or more after the baseline examination in 21 of the IRBD patients and 14 of the PD patients.
RESULTS: There were no significant differences in the mean right or left VN-CSA between the three groups. The mean left VN-CSA was significantly reduced in IRBD after a mean follow-up period of 2.3 ± 0.9 years (P = 0.0069). In the PD group, a negative correlation between motor function (assessed by the MDS-UPDRS part III) and the VN-CSA.
CONCLUSIONS: Repeatedly monitoring the left VN-CSA might serve as an indicator of IRBD progression. The VN-CSA may be further reduced in PD compared with IRBD. These data comparing changes in the VN-CSA over time in patients with IRBD and early PD provide a starting point for future research.