Seminars in arthritis and rheumatism · 2025
Overall and by subtype epidemiology of idiopathic inflammatory myopathies among African descent patients with free access to high standard healthcare.
СтатьяНазвание и аннотация: Перевод в очереди
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Abel Aurore, Robert Rachel, Felix Arthur, Coco-Viloin Illitch, Moinet Florence, Bellance Remi, Amazan Emmanuelle, Agossou Moustapha, Pierrisnard Emma, Louis-Sidney Fabienne, Deligny Christophe, Suzon Benoit
Аннотация
OBJECTIVE: To describe the epidemiology, characteristics and evolution of African descent patients with IIM in the Caribbean Island of Martinique with free access to high standard socialized healthcare.
METHODS: Retrospective longitudinal study from January 1, 2000 to June 2023 at the University Hospital of Martinique, the island's only tertiary care center. Patients with clinically myopathic or amyopathic adult-onset dermatomyositis (DM), polymyositis (PM), anti-synthetase syndrome (ASyS), immune-mediated necrotizing myositis (IMNM), overlap myositis (OM) were included. Baseline clinical, immunological, radiological characteristics, and treatments were collected along with occurrence of relapses and deaths RESULTS: Mean IIM incidence was 2.34/100,000. The 2022 prevalence of IIM reached 32.2/100,000 inhabitants, with variations between subtypes. 174 patients were included, of whom 55 (32 %) had ASyS, 44 (25 %) OM, 44 (25 %) DM, 16 (9 %) PM, 14 (8 %) IMNM and 1 (0.6 %) IBM. Median time from first symptoms to diagnosis was 4.2 months [2.0 to 12.3]. Anti-Jo1, anti-PL12 and anti-SRP were the most frequent myositis specific autoantibody detected. Most frequent manifestations were arthralgia (65 %), muscle weakness (61 %) and skin DM lesions (53 %). At diagnosis, 77 (52 %) and 28 patients (16 %) had interstitial lung disease (ILD) and cardiac involvement, respectively. ASyS was more frequently clinically amyopathic (p < 0.05) and had more frequently ILD (p < 0.05). After treatments, sixty-nine patients (40 %) relapsed in a median time of 2.8 years [1.1 to 7.2].
CONCLUSION: There is a high incidence and prevalence of IIM in the Caribbean Island of Martinique, and a pulmonary and cardiac threat at IIM diagnosis in African descent population.
METHODS: Retrospective longitudinal study from January 1, 2000 to June 2023 at the University Hospital of Martinique, the island's only tertiary care center. Patients with clinically myopathic or amyopathic adult-onset dermatomyositis (DM), polymyositis (PM), anti-synthetase syndrome (ASyS), immune-mediated necrotizing myositis (IMNM), overlap myositis (OM) were included. Baseline clinical, immunological, radiological characteristics, and treatments were collected along with occurrence of relapses and deaths RESULTS: Mean IIM incidence was 2.34/100,000. The 2022 prevalence of IIM reached 32.2/100,000 inhabitants, with variations between subtypes. 174 patients were included, of whom 55 (32 %) had ASyS, 44 (25 %) OM, 44 (25 %) DM, 16 (9 %) PM, 14 (8 %) IMNM and 1 (0.6 %) IBM. Median time from first symptoms to diagnosis was 4.2 months [2.0 to 12.3]. Anti-Jo1, anti-PL12 and anti-SRP were the most frequent myositis specific autoantibody detected. Most frequent manifestations were arthralgia (65 %), muscle weakness (61 %) and skin DM lesions (53 %). At diagnosis, 77 (52 %) and 28 patients (16 %) had interstitial lung disease (ILD) and cardiac involvement, respectively. ASyS was more frequently clinically amyopathic (p < 0.05) and had more frequently ILD (p < 0.05). After treatments, sixty-nine patients (40 %) relapsed in a median time of 2.8 years [1.1 to 7.2].
CONCLUSION: There is a high incidence and prevalence of IIM in the Caribbean Island of Martinique, and a pulmonary and cardiac threat at IIM diagnosis in African descent population.