Regenerative Evaluation of Collagen and an Advanced Platelet-rich Fibrin Membranes with Deproteinized Bovine Bone Matrix in Infrabony Defects: A Randomized Controlled Trial.

AIM: This study aimed to compare the effectiveness of bioresorbable collagen membrane and an advanced platelet-rich fibrin (A-PRF) membrane, both combined with deproteinized bovine bone matrix (DBBM) xenograft, in the treatment of human infrabony defects.

MATERIALS AND

METHODS

Twenty-four patients (aged 28-54 years) with moderate to advanced periodontitis and infrabony defects were randomly assigned to two groups. Group A received open flap debridement with deproteinized DBBM xenograft and a bioresorbable collagen membrane, while group B received DBBM with A-PRF. Clinical parameters, including probing pocket depth (PPD), clinical attachment level (CAL), gingival recession, radiographic bone fill, and oral hygiene status, were assessed at baseline and 6 months postoperatively.

RESULTS

At the 6-month follow-up after regenerative procedures, both treatment groups showed improvements in clinical parameters and radiographic bone gain. At 6 months, no significant difference in CAL gain was found between group A (3.5 ± 0.79 mm) and group B (3.66 ± 0.88 mm), with a mean difference of 0.16 ± 1.26 mm (p > 0.05). Additionally, the radiographic bone fill (%BF) in the DBBM + collagen membrane group was comparable to that in the DBBM + A-PRF membrane group, with no statistically significant difference.

CONCLUSIONS

Within the limitations of this study, the combination of DBBM and a collagen membrane (group A) resulted in significantly more favorable clinical outcomes in terms of radiographic bone fill for infrabony defects as compared to group B.

CLINICAL SIGNIFICANCE: Both collagen and A-PRF membranes with DBBM significantly improved clinical and radiographic outcomes in treating infrabony defects. Advanced platelet-rich fibrin offers a promising autologous alternative to collagen, supporting effective periodontal regeneration without animal-derived barriers. How to cite this article: Bhagat S, Jaiswal P, Bajaj P, et al. Regenerative Evaluation of Collagen and an Advanced Platelet-rich Fibrin Membranes with Deproteinized Bovine Bone Matrix in Infrabony Defects: A Randomized Controlled Trial. J Contemp Dent Pract 2025;26(6):573-580.