Oral oncology · 2025
Fear of cancer recurrence in adults with p16-positive head and neck cancer after radiotherapy - Results from a multicenter cross-sectional observational study.
СтатьяНаблюдательное исследованиеМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Boide Anna, Glasmacher Andrea Renate, Wurschi Georg, Tews Anna-Maria, Seidel Clemens, Pannenbecker Charlotte, Dietz Andreas, Guntinas-Lichius Orlando, Mehnert-Theuerkauf Anja, Gkika Eleni, Leitzen Christina, Pietschmann Klaus, Nicolay Nils Henrik, Rühle Alexander
Аннотация
PURPOSE: To examine the prevalence of fear of cancer recurrence (FCR) in adults with p16-positive head and neck cancer after (chemo)radiation, with a particular focus on the influence of clinical and psychosocial factors on its severity.
METHODS: This cross-sectional observational study was conducted at three university cancer centers to assess FCR in adults with p16-positive oropharynx cancer or cancer of unknown primary in the head and neck undergoing (chemo)radiation between 2018 and 2024. FCR was measured using the short version of the Fear of Progression (FoP-Q-12) questionnaire and was compared to p16-negative head and neck cancer (oral cavity, oropharynx, hypopharynx, larynx) survivors (n = 95).
RESULTS: Of 139 eligible patients, 118 were contacted, and 77 consented to participate. Median age at the start of radiotherapy was 61 years (IQR, 57-66), and most were male (n = 56, 73 %). Twenty-one patients (27 %) received definitive (chemo)radiation. Strong FCR (≥34 points) was reported by 16 patients (21 %). P16-positive head and neck cancer survivors reported less FCR than patients with p16-negative tumors (p < 0.0001). FCR was negatively correlated with global quality of life (r = -0.32, p < 0.01) and positively with distress (r = 0.37, p < 0.01), decision regret (r = 0.41, p < 0.001), depression (r = 0.58, p < 0.001) and anxiety (r = 0.72, p < 0.001). No associations were found between FCR and age, gender, performance status, smoking, T classification, N classification, type of treatment, and time between radiotherapy and questionnaire completion.
CONCLUSIONS: Strong FCR affected about one-fifth of p16-positive head and neck cancer survivors and was associated with lower quality of life as well as higher distress, depression, and anxiety.
METHODS: This cross-sectional observational study was conducted at three university cancer centers to assess FCR in adults with p16-positive oropharynx cancer or cancer of unknown primary in the head and neck undergoing (chemo)radiation between 2018 and 2024. FCR was measured using the short version of the Fear of Progression (FoP-Q-12) questionnaire and was compared to p16-negative head and neck cancer (oral cavity, oropharynx, hypopharynx, larynx) survivors (n = 95).
RESULTS: Of 139 eligible patients, 118 were contacted, and 77 consented to participate. Median age at the start of radiotherapy was 61 years (IQR, 57-66), and most were male (n = 56, 73 %). Twenty-one patients (27 %) received definitive (chemo)radiation. Strong FCR (≥34 points) was reported by 16 patients (21 %). P16-positive head and neck cancer survivors reported less FCR than patients with p16-negative tumors (p < 0.0001). FCR was negatively correlated with global quality of life (r = -0.32, p < 0.01) and positively with distress (r = 0.37, p < 0.01), decision regret (r = 0.41, p < 0.001), depression (r = 0.58, p < 0.001) and anxiety (r = 0.72, p < 0.001). No associations were found between FCR and age, gender, performance status, smoking, T classification, N classification, type of treatment, and time between radiotherapy and questionnaire completion.
CONCLUSIONS: Strong FCR affected about one-fifth of p16-positive head and neck cancer survivors and was associated with lower quality of life as well as higher distress, depression, and anxiety.