Acta cirurgica brasileira · 2026
The beneficial effects of leave extract of Commiphora leptophloeos on intestinal mucositis induced by 5-fluorouracil in mice.
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Silva Amanda Silveira da, Barbosa Stephannie Jamyla de Araújo, Ribeiro Susana Barbosa, Carvalho Lucas Vinicius Souza de, Silva Rafaela Torres Dantas da, Guerra Gerlane Coelho Bernardo, Araújo Júnior Raimundo Fernandes de, Silva Nizyara Costa da, Andrade Raphael Victor Silva, Paiva Gabrielle Marques de, Langassner Silvana Maria Zucolotto, Dantas-Medeiros Renato, Fé Rafaela Alcindo Silva de Sousa, Lima Maria Laura de Souza, Araújo Aurigena Antunes de
Аннотация
PURPOSE: This study aimed to evaluate the effect of oral administration of a hydroethanolic extract of Commiphora leptophloeos leaves (CLF) on the progression of 5-fluorouracil (5-FU)-induced intestinal mucositis.
METHODS: Female Swiss mice were orally administered CLF at doses of 10, 100, or 300 mg/kg, or saline (negative control, NC), starting 30 minutes before intraperitoneal injection of 5-FU. A positive control (PC) group received 5-FU without CLF treatment. Treatment continued until euthanasia, three days after 5-FU injection. Body weight was monitored throughout the experiment. On day 4, small intestine tissue samples were collected for histopathological analysis. Duodenal tissue was also assessed for Muc-2 immunostaining.
RESULTS: In the CLF 10, 100 and 300 mg/kg groups, the duodenum histopathological score was 1 (1-1.5) p < 0.001, 1 (1-1.5) p < 0.01; 1 (1-1.25) p < 0.01, while the PC group score was 2 (2-2.75). Immunostaining analysis for Muc-2 revealed a score of 3 (3-3) in the CLF 10 group, compared to score 1.2 (0.8-1.6) in the PC group (p < 0.001), indicating that CLF 10 increased Muc-2 expression.
CONCLUSION: The oral administration of a hydroethanolic extract of CLF protected the duodenal segment of Swiss mice from 5-FU-induced intestinal mucositis, likely by increasing mucin production.
METHODS: Female Swiss mice were orally administered CLF at doses of 10, 100, or 300 mg/kg, or saline (negative control, NC), starting 30 minutes before intraperitoneal injection of 5-FU. A positive control (PC) group received 5-FU without CLF treatment. Treatment continued until euthanasia, three days after 5-FU injection. Body weight was monitored throughout the experiment. On day 4, small intestine tissue samples were collected for histopathological analysis. Duodenal tissue was also assessed for Muc-2 immunostaining.
RESULTS: In the CLF 10, 100 and 300 mg/kg groups, the duodenum histopathological score was 1 (1-1.5) p < 0.001, 1 (1-1.5) p < 0.01; 1 (1-1.25) p < 0.01, while the PC group score was 2 (2-2.75). Immunostaining analysis for Muc-2 revealed a score of 3 (3-3) in the CLF 10 group, compared to score 1.2 (0.8-1.6) in the PC group (p < 0.001), indicating that CLF 10 increased Muc-2 expression.
CONCLUSION: The oral administration of a hydroethanolic extract of CLF protected the duodenal segment of Swiss mice from 5-FU-induced intestinal mucositis, likely by increasing mucin production.