Journal of drugs in dermatology : JDD · 2026
Body Contouring By Ultrasound-Induced Lipolysis.
СтатьяНазвание и аннотация: Перевод в очереди
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Kapxhiu Gerta, Blokh Anna, Orenstein Arie
Аннотация
BACKGROUND: The body contouring market has undergone a paradigm shift from invasive surgical procedures to advanced noninvasive treatments. Noninvasive fat-reducing devices based on nonfocused ultrasound waves induce lipolysis and ultimately reduce body fat, with minimal discomfort and downtime.
METHODS: A dosimetry analysis was conducted on skin of domesticated pigs to increasing doses of low-intensity ultrasound, followed by histological analysis of skin biopsies collected up to 14 days post-treatment. The clinical impact of ultrasound was retrospectively assessed by comparing skin laxity in before-and-after photographs of abdominal and facial regions subjected to up to 8 treatment sessions, at 7- to 14-day intervals. Circumference reduction and patient-rated pain and satisfaction levels were extracted from patient records.
RESULTS: Histological analysis of pig biopsy samples identified that treatment with ultrasound damages subcutaneous fat at cellular and tissue levels, without impact on neurovascular bundles, epidermal or dermal layers. Seventy-four (74) patients were treated in facial (2.3%) or abdominal, buttocks, or thigh (79.7%) areas, and followed up for 2 to 3 weeks after the last session. The ultrasound regimen induced a significant reduction in abdominal circumference (2.6±1.2 cm). Physician-rated improvements were significant in 57.9% of patients treated at the abdomen, trunk, or thighs, and 20.0% (3/15) of facial areas, with a positive correlation found between degree of improvement, number of sessions (rs=0.365, P=.002), and inter-session interval length (rs=0.257, P=.003). Treatment was highly tolerable, and patients were very satisfied with the outcomes.
CONCLUSION: Nonfocused ultrasound is a safe and effective technology to reduce body fat, particularly in the abdominal area.  .
METHODS: A dosimetry analysis was conducted on skin of domesticated pigs to increasing doses of low-intensity ultrasound, followed by histological analysis of skin biopsies collected up to 14 days post-treatment. The clinical impact of ultrasound was retrospectively assessed by comparing skin laxity in before-and-after photographs of abdominal and facial regions subjected to up to 8 treatment sessions, at 7- to 14-day intervals. Circumference reduction and patient-rated pain and satisfaction levels were extracted from patient records.
RESULTS: Histological analysis of pig biopsy samples identified that treatment with ultrasound damages subcutaneous fat at cellular and tissue levels, without impact on neurovascular bundles, epidermal or dermal layers. Seventy-four (74) patients were treated in facial (2.3%) or abdominal, buttocks, or thigh (79.7%) areas, and followed up for 2 to 3 weeks after the last session. The ultrasound regimen induced a significant reduction in abdominal circumference (2.6±1.2 cm). Physician-rated improvements were significant in 57.9% of patients treated at the abdomen, trunk, or thighs, and 20.0% (3/15) of facial areas, with a positive correlation found between degree of improvement, number of sessions (rs=0.365, P=.002), and inter-session interval length (rs=0.257, P=.003). Treatment was highly tolerable, and patients were very satisfied with the outcomes.
CONCLUSION: Nonfocused ultrasound is a safe and effective technology to reduce body fat, particularly in the abdominal area.  .