Cribriform Adenocarcinoma of the Nasal Cavity Harboring a Novel NAP1L1::PRKD1 Fusion, Expanding the Molecular Landscape of Minor Salivary Gland Tumors.

Cribriform adenocarcinoma of the salivary glands (CASG) is a rare tumor of minor salivary glands, predominantly of the oral cavity, characterized by distinct morphologic and immunophenotypic features. In this article, we describe a unique case of CASG arising in the sinonasal cavity of a 49-year-old female, with a novel NAP1L1::PRKD1 fusion, expanding the molecular complexities of salivary gland neoplasms. This neoplasm showed typical morphology with nests of tumor cells with cribriform and papillary architecture and a classic immunohistochemical profile with tumor cells positive for S100 and p63 while negative for p40. Molecular studies showed a NAP1L1::PRKD1 fusion, which has not been previously detected in cribriform adenocarcinoma.