Frontiers in oncology · 2025
Ectopic breast fibroadenoma of the vulva: a case report.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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He Yixiao, Xie Gang, Ji Yuzhu, Shi Yu, He Yushuang, Lei Xue
Аннотация
BACKGROUND: Vulvar ectopic breast fibroadenoma (EBF) is an exceptionally rare benign neoplasm that lacks distinctive clinical or radiological features rendering pre-operative differentiation from other vulvar masses challenging. Definitive diagnosis requires histopathological confirmation. Two non-exclusive histogenetic hypotheses have been proposed: (1) derivation from ectopic breast tissue along the embryonic "milk line," (2) origin from hormonally responsive anogenital mammary-like glands with latent potential for benign or malignant transformation.
CASE PRESENTATION: A 41-year-old woman presented with an incidentally discovered, slowly enlarging, painless right vulvar mass. Ultrasonography revealed a well-circumscribed hypoechoic nodule. Complete surgical excision was performed, and histopathological evaluation-including immunohistochemistry for estrogen receptor, progesterone receptor, GATA3, and p63-confirmed ectopic breast fibroadenoma. No recurrence was detected at 3-month follow-up.
CONCLUSION: Despite its rarity, vulvar EBF must be considered in the differential diagnosis of vulvar masses in reproductive-age women. En-bloc excision is curative; however, long-term surveillance is warranted to monitor for hormone-driven recurrence or malignant evolution.
CASE PRESENTATION: A 41-year-old woman presented with an incidentally discovered, slowly enlarging, painless right vulvar mass. Ultrasonography revealed a well-circumscribed hypoechoic nodule. Complete surgical excision was performed, and histopathological evaluation-including immunohistochemistry for estrogen receptor, progesterone receptor, GATA3, and p63-confirmed ectopic breast fibroadenoma. No recurrence was detected at 3-month follow-up.
CONCLUSION: Despite its rarity, vulvar EBF must be considered in the differential diagnosis of vulvar masses in reproductive-age women. En-bloc excision is curative; however, long-term surveillance is warranted to monitor for hormone-driven recurrence or malignant evolution.