Kaposi's sarcoma as manifestation of immunosuppression in organ transplant recipients.

We report 2 patients, negative for human immunodeficiency virus (HIV) antibodies, who developed generalized Kaposi's sarcoma (KS), one 5 months after renal transplantation while receiving cyclosporin A and prednisone, and the other 24 months after heart transplantation while receiving cyclosporin A, azathioprine and prednisone. Reduction of the immunosuppressive therapy combined with chemotherapy and radiotherapy in both cases led to a remission of KS without development of transplant rejection.