Association between interleukin-10 (IL-10) genetic polymorphisms and non-hodgkin lymphoma: a systematic review and meta-analysis.

Non-Hodgkin lymphoma (NHL) has been associated with IL-10 single-nucleotide polymorphisms (SNPs), although findings remain inconsistent. This meta-analysis aims to investigate the association between key IL-10 SNPs (rs1800871, rs1800872, rs1800890, and rs1800896) with NHL. A systematic search of multiple databases was conducted to get relevant articles. The study included 53,864 cases and 60,448 controls from 41 studies. Pooled ORs with 95% CIs were calculated for each SNP, along with a heterogeneity test and publication bias analysis. The SNP rs1800890 showed modest but significant associations with NHL risk in codominant 1 (OR = 1.12, p < 0.001), codominant 2 (OR = 1.06, p = 0.006), and recessive models (OR = 1.08, p = 0.002); rs1800896 showed weak significant associations with NHL risk in dominant (OR = 1.08, p = 0.001) and codominant 2 models (OR = 1.07, p = 0.006). Subgroup analysis based on ethnicity revealed a nominally significant protective association in Caucasians for rs1800871 in the allelic model (OR = 0.87, p = 0.038).