Nuclear medicine communications · 2026
Prognostic value of baseline 18F- fluroodexoygloucose PET/computed tomography-derived maximum standardized uptake value and tumor bulk in pediatric Hodgkin lymphoma: a retrospective analysis.
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Nazir Nadia, Sikandar Zeeshan, Afzal Faiza, Khattak Aruba Nawaz, Rehman Anis Ur, Javed Khalid, Sindhu Irfana Ishaq
Аннотация
OBJECTIVE: This study aimed to evaluate the prognostic significance of baseline 18F-fluorodeoxyglucose PET/computed tomography-derived metabolic tumor volume (MTV) and maximum standardized uptake value (SUVmax) for treatment outcome in pediatric Hodgkin lymphoma.
METHODS: We retrospectively analyzed 48 patients aged less than or equal to 18 years with newly diagnosed intermediate-risk Hodgkin lymphoma who underwent baseline 18F-fluorodeoxyglucose PET/computed tomography between January 2020 and December 2025 at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan. Baseline MTV and SUVmax were quantified and assessed for association with treatment outcomes. The primary endpoint was event-free survival (EFS).
RESULTS: Median baseline MTV was 263.5 ml (range: 22-781) and median SUVmax was 9.2 (range: 3.2-31.8). After a median follow-up of 48.8 months, 14 (29.2%) patients experienced an EFS event. MTV was higher in patients with events than in those without (303.0 vs. 254.5 ml), but the difference was not significant (P = 0.212). SUVmax was also nonpredictive (P = 0.834). EFS was 63.6% in the high-MTV group versus 86.7% in the low-MTV group (Fisher's exact P = 0.171; log-rank P = 0.194). MTV and SUVmax showed a weak, nonsignificant correlation (ρ = 0.173, P = 0.244). Disease stage was the only significant prognostic factor (P = 0.010). Receiver operating characteristics analysis demonstrated modest discriminatory ability for MTV [area under the curve (AUC) = 0.617], whereas SUVmax showed none (AUC = 0.479).
CONCLUSION: In this single-center cohort, baseline MTV and SUVmax were not significantly predictive of EFS, with disease stage remained the only significant prognostic determinant. However, given the limited statistical power inherent to this sample size, a clinically meaningful association cannot be excluded and warrants evaluation in larger prospective studies.
METHODS: We retrospectively analyzed 48 patients aged less than or equal to 18 years with newly diagnosed intermediate-risk Hodgkin lymphoma who underwent baseline 18F-fluorodeoxyglucose PET/computed tomography between January 2020 and December 2025 at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan. Baseline MTV and SUVmax were quantified and assessed for association with treatment outcomes. The primary endpoint was event-free survival (EFS).
RESULTS: Median baseline MTV was 263.5 ml (range: 22-781) and median SUVmax was 9.2 (range: 3.2-31.8). After a median follow-up of 48.8 months, 14 (29.2%) patients experienced an EFS event. MTV was higher in patients with events than in those without (303.0 vs. 254.5 ml), but the difference was not significant (P = 0.212). SUVmax was also nonpredictive (P = 0.834). EFS was 63.6% in the high-MTV group versus 86.7% in the low-MTV group (Fisher's exact P = 0.171; log-rank P = 0.194). MTV and SUVmax showed a weak, nonsignificant correlation (ρ = 0.173, P = 0.244). Disease stage was the only significant prognostic factor (P = 0.010). Receiver operating characteristics analysis demonstrated modest discriminatory ability for MTV [area under the curve (AUC) = 0.617], whereas SUVmax showed none (AUC = 0.479).
CONCLUSION: In this single-center cohort, baseline MTV and SUVmax were not significantly predictive of EFS, with disease stage remained the only significant prognostic determinant. However, given the limited statistical power inherent to this sample size, a clinically meaningful association cannot be excluded and warrants evaluation in larger prospective studies.