Gan to kagaku ryoho. Cancer & chemotherapy · 2025
[A Case of Successful Combination of Immune Checkpoint Inhibitors and Radiotherapy for MLH1 Gene-Deficient Colon Cancer].
СтатьяКлинический случайАннотация на английскомНазвание и аннотация: Перевод в очереди
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Shimizu Yosuke, Sada Haruki, Shimada Norimitsu, Miyata Masahide, Fukuda Takahiro, Ono Michie, Fujii Tomomasa, Shibata Yoshiyuki, Taduma Sho, Tanimine Naoki, Tazawa Hirofumi, Suzuki Takahisa, Onoe Takashi, Sudo Takeshi, Tashiro Hirotaka
Аннотация
A 77-year-old woman was diagnosed with advanced transverse colon cancer(poorly differentiated adenocarcinoma)cT3N3H0P0, cStage Ⅲc and underwent extended left hemicolectomy in April 2020. The tumor tissue revealed RAS: wild type, BRAF: mutant type, dMMR(MLH1 deficiency)by immunochemical staining, and MSI-H by CDx. She received CAPOX as adjuvant chemotherapy after surgery. At the end of the 3 courses, she developed abdominal aortic lymph nodes recurrence( diameter 32×18 mm)and began to receive pembrolizumab therapy in August 2020. But the tumor re-grew 6 months after the start of this regimen. However the recurrent lesion was localized, radiation therapy(IMRT: 54 Gy/27 Fr) was added in combination with pembrolizumab. Two months later the tumor had shrunk significantly. As of June 2024, the patient has remained recurrence-free, suggesting that the abscopal effect may have been involved by immuno-radiotherapy in this case.