International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2025
Evaluating the risk of diaphragmatic hernia following left diaphragm resections during cytoreductive surgery for ovarian cancer: a Memorial Sloan Kettering Cancer Center Team Ovary study.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Kahn Ryan M, Anderson Sarah, Yeoshoua Effi, Harlev Christina, Ehmann Sarah, Zhou Qin, Iasonos Alexia, Abu-Rustum Nadeem R, Al-Niaimi Ahmed, Broach Vance, Gardner Ginger J, Long Kara C, Sonoda Yukio, Zivanovic Oliver, Chi Dennis S
Аннотация
OBJECTIVE: To determine the incidence rate and risk factors associated with the development of diaphragm hernias following left diaphragm procedures at the time of ovarian cancer cytoreduction.
METHODS: We retrospectively reviewed data from patients diagnosed with epithelial ovarian, fallopian tube, or primary peritoneal carcinoma who underwent any timeframe of cytoreductive surgery (primary, interval, secondary, tertiary) at our institution from December 2010 to September 2024. Patients were included if they underwent left diaphragm peritonectomy or resection as part of their cytoreductive surgery. The diagnosis of left diaphragm hernia was made by computed tomography of the chest either as an incidental finding during follow-up surveillance or during work-up for symptomatology. We utilized statistical analysis with descriptive proportions with interquartile ranges.
RESULTS: A total of 267 patients with ovarian cancer underwent a left diaphragm peritonectomy or resection as part of their cytoreductive surgery at our institution and were included in the study. The overall median age was 62 years (interquartile range; 52-70) and body mass index 24.9 kg/m2 (interquartile range; 22.1-28.5). Overall, 2.2% (6/267) of patients developed a left diaphragmatic hernia, with 33% (2/6) following a primary cytoreduction and 67% (4/6) following an interval cytoreduction; in addition, 83% (5/6) had a splenectomy at the time of cytoreduction. The median time from date of surgery to time of diagnosis was 12.3 months (range; 4.8-24.8). On univariate analysis, the OR of developing a left diaphragm hernia after undergoing splenectomy was 3.2 (p = .24).
CONCLUSIONS: Diaphragmatic hernias occurred most often following the setting of concurrent splenectomy; however, splenectomy was not a statistically significant risk factor. These findings provide meaningful insight into the frequency and clinical context in which this complication may arise, addressing a critical knowledge gap in the surgical management of patients with ovarian cancer who require upper abdominal and thoracic procedures.
METHODS: We retrospectively reviewed data from patients diagnosed with epithelial ovarian, fallopian tube, or primary peritoneal carcinoma who underwent any timeframe of cytoreductive surgery (primary, interval, secondary, tertiary) at our institution from December 2010 to September 2024. Patients were included if they underwent left diaphragm peritonectomy or resection as part of their cytoreductive surgery. The diagnosis of left diaphragm hernia was made by computed tomography of the chest either as an incidental finding during follow-up surveillance or during work-up for symptomatology. We utilized statistical analysis with descriptive proportions with interquartile ranges.
RESULTS: A total of 267 patients with ovarian cancer underwent a left diaphragm peritonectomy or resection as part of their cytoreductive surgery at our institution and were included in the study. The overall median age was 62 years (interquartile range; 52-70) and body mass index 24.9 kg/m2 (interquartile range; 22.1-28.5). Overall, 2.2% (6/267) of patients developed a left diaphragmatic hernia, with 33% (2/6) following a primary cytoreduction and 67% (4/6) following an interval cytoreduction; in addition, 83% (5/6) had a splenectomy at the time of cytoreduction. The median time from date of surgery to time of diagnosis was 12.3 months (range; 4.8-24.8). On univariate analysis, the OR of developing a left diaphragm hernia after undergoing splenectomy was 3.2 (p = .24).
CONCLUSIONS: Diaphragmatic hernias occurred most often following the setting of concurrent splenectomy; however, splenectomy was not a statistically significant risk factor. These findings provide meaningful insight into the frequency and clinical context in which this complication may arise, addressing a critical knowledge gap in the surgical management of patients with ovarian cancer who require upper abdominal and thoracic procedures.