International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2026
Effect of high-intensity focused ultrasound ablation on lesion stiffness and symptoms of adenomyosis.
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Shen Xuan, Chen Wenzhi, Shi Qiuling, Zi Dan, Ren Xiaoyu, Tian Xin
Аннотация
OBJECTIVES: To investigate the relationship between lesion stiffness and symptoms of patients and to evaluate the effectiveness of high-intensity focused ultrasound ablation (HIFUa) against lesion stiffness and symptoms of patients with adenomyosis.
METHODS: A total of 124 patients with adenomyosis treated with HIFUa were included. Baseline characteristics and adenomyotic lesion stiffness were collected to identify factors associated with stiffness. Data on the changes of uterine lesion stiffness (E value), the menstrual volume score (PBAC), and the dysmenorrhea numeric rating scale (NRS) score before and 1, 3, and 6 months after HIFUa treatment in 42 patients were collected to explore the effects of HIFUa on stiffness and symptom changes.
RESULTS: Before HIFUa, adenomyotic lesion stiffness was significantly greater than that of the normal myometrium. Adenomyotic lesion stiffness was significantly positively correlated with moderate to severe dysmenorrhea (r = 0.731), however, there was no significant linear correlation with hypermenorrhea (r = 0.153). Compared with that at pretreatment, stiffness at 3 and 6 months significantly decreased (that is, the elasticity increased) (p < 0.01). The NRS and PBAC scores at 1, 3, and 6 months were significantly lower than those at before HIFUa (p < 0.01), and the decrease in the NRS score was related to the decrease in stiffness.
CONCLUSION: For adenomyosis patients with moderate to severe dysmenorrhea, lesion stiffness has been proven to be an objective reflection of dysmenorrhea severity. Lesion stiffness can be used as an imaging index to evaluate dysmenorrhea severity. Dysmenorrhea relief after HIFUa is related to decreased lesion stiffness.
METHODS: A total of 124 patients with adenomyosis treated with HIFUa were included. Baseline characteristics and adenomyotic lesion stiffness were collected to identify factors associated with stiffness. Data on the changes of uterine lesion stiffness (E value), the menstrual volume score (PBAC), and the dysmenorrhea numeric rating scale (NRS) score before and 1, 3, and 6 months after HIFUa treatment in 42 patients were collected to explore the effects of HIFUa on stiffness and symptom changes.
RESULTS: Before HIFUa, adenomyotic lesion stiffness was significantly greater than that of the normal myometrium. Adenomyotic lesion stiffness was significantly positively correlated with moderate to severe dysmenorrhea (r = 0.731), however, there was no significant linear correlation with hypermenorrhea (r = 0.153). Compared with that at pretreatment, stiffness at 3 and 6 months significantly decreased (that is, the elasticity increased) (p < 0.01). The NRS and PBAC scores at 1, 3, and 6 months were significantly lower than those at before HIFUa (p < 0.01), and the decrease in the NRS score was related to the decrease in stiffness.
CONCLUSION: For adenomyosis patients with moderate to severe dysmenorrhea, lesion stiffness has been proven to be an objective reflection of dysmenorrhea severity. Lesion stiffness can be used as an imaging index to evaluate dysmenorrhea severity. Dysmenorrhea relief after HIFUa is related to decreased lesion stiffness.