Foveolar-Type Gastric Adenoma With a Raspberry-Like Appearance That Underwent Dramatic Morphological Changes Within Eight Months.

BACKGROUND

Foveolar-type gastric adenomas with a raspberry-like appearance in the stomach have recently been identified. However, their etiology and mechanisms of development and growth remain unknown.

CASE PRESENTATION: We observed a foveolar-type gastric adenoma with a raspberry-like appearance that underwent rapid morphological changes. The first esophagogastroduodenoscopy revealed multiple reddish polyps on the cardia and fundus of the stomach, without Helicobacter pylori infection. The second-largest polyp on the fundus had a red glove appearance and measured 5 mm in diameter. We diagnosed all of them as hyperplastic polyps on the basis of their shape. Given that the patient had received 10 mg of vonoprazan for a long time to treat reflux esophagitis, 20 mg of famotidine was prescribed instead. Eight months later, the largest polyp on the cardia had disappeared.However, a reddish raspberry-like lesion was observed at the site of a previously identified polyp on the fundus and was diagnosed as foveolar-type gastric adenoma by forceps biopsy. The pathological diagnosis was foveolar-type gastric adenoma with high-grade dysplasia as determined by tissue resection with endoscopic mucosal resection (EMR).

CONCLUSION

This is a valuable case report of a lesion evolving from a hyperplastic-like polyp morphology to a raspberry-like lesion within eight months.