18 F-FDG PET/CT in NUT Carcinoma of the Thorax.

NUT carcinoma (NUTc) is a rare, aggressive cancer characterized by rearrangement of the NUTM1 gene on chromosome 15q14. We present the case of a 32-year-old man with a persisting cough, reduced general condition, and B symptoms for 2 months. CT imaging revealed a highly suspicious mass in the right lung, infiltrating hilar structures, and the mediastinum. Staging with 18 F-FDG PET/CT demonstrated pathologic 18 F-FDG uptake within the tumor. Histology, immunohistochemistry, and molecular analysis confirmed NUTc of the lung. Metabolic imaging modalities may play a key role in staging, restaging, and assessing treatment response in patients with NUTc.