Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) · 2026
Factors predicting fluid-free retina and complete polypoidal regression in polypoidal choroidal vasculopathy eyes receiving 2-mg aflibercept treatments.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Chaikitmongkol Voraporn, Somkuna Thidarat, Patikulsila Direk, Ruamviboonsuk Paisan, Jirarattanasopa Pichai, Srisomboon Titipol, Narongchai Chanusnun, Ratanasukon Mansing, Bhurayanontachai Patama, Kunavisarut Paradee, Watanachai Nawat, Choovuthayakorn Janejit, Chotcomwongse Peranut, Sangkaew Apisara, Ingviya Thammasin, Bressler Neil M
Аннотация
PURPOSE: To determine predictive factors for fluid-free retina and complete polypoidal choroidal vasculopathy (PCV) regression following 1-year aflibercept monotherapy in PCV.
METHODS: Multicenter, retrospective cohort of treatment-naïve PCV eyes receiving 2-mg aflibercept treatments for 1 year from 2015 to 2018 collected demographic data, de-identified fundus photography, optical coherence tomography (OCT), and indocyanine green angiography (ICGA) images at baseline and 1-year of study eyes were graded to identify baseline features and outcomes.
RESULTS: Of 100 study eyes, mean age [SD] was 63.8 [8] years; 100% were Thai patients. At 1 year, eighty-five eyes (85%) had fluid-free retina; 48 eyes (48%) had complete polypoidal regression. Multivariate analyses showed baseline OCT and ICGA features associated with 1-year outcomes: sharply-peaked PED with/without double-layer sign on OCT and smaller lesion size on ICGA (<1 disc diameter) were associated with fluid-free retina (OR 6.57; 95%CI 1.27-34.10, and OR 7.86; 95%CI 1.33-46.54, respectively). Multilobulated PED on OCT was associated with poor (20/200 or worse) final VA (OR 4.53; 95%CI 1.33-15.36). Smaller number (1-5) of polypoidal lesions on ICGA was associated with complete polypoidal regression (OR 4.87; 95%CI 1.44-16.43) CONCLUSION: Results suggest baseline OCT and ICGA features could predict fluid-free retina and complete polypoidal regression following aflibercept monotherapy.
METHODS: Multicenter, retrospective cohort of treatment-naïve PCV eyes receiving 2-mg aflibercept treatments for 1 year from 2015 to 2018 collected demographic data, de-identified fundus photography, optical coherence tomography (OCT), and indocyanine green angiography (ICGA) images at baseline and 1-year of study eyes were graded to identify baseline features and outcomes.
RESULTS: Of 100 study eyes, mean age [SD] was 63.8 [8] years; 100% were Thai patients. At 1 year, eighty-five eyes (85%) had fluid-free retina; 48 eyes (48%) had complete polypoidal regression. Multivariate analyses showed baseline OCT and ICGA features associated with 1-year outcomes: sharply-peaked PED with/without double-layer sign on OCT and smaller lesion size on ICGA (<1 disc diameter) were associated with fluid-free retina (OR 6.57; 95%CI 1.27-34.10, and OR 7.86; 95%CI 1.33-46.54, respectively). Multilobulated PED on OCT was associated with poor (20/200 or worse) final VA (OR 4.53; 95%CI 1.33-15.36). Smaller number (1-5) of polypoidal lesions on ICGA was associated with complete polypoidal regression (OR 4.87; 95%CI 1.44-16.43) CONCLUSION: Results suggest baseline OCT and ICGA features could predict fluid-free retina and complete polypoidal regression following aflibercept monotherapy.
Предметные рубрики MeSH
HumansRecombinant Fusion ProteinsReceptors, Vascular Endothelial Growth FactorPolypoidal Choroidal VasculopathyFemaleRetrospective StudiesMaleTomography, Optical CoherenceFluorescein AngiographyAngiogenesis InhibitorsIntravitreal InjectionsVisual AcuityMiddle AgedFundus OculiChoroidFollow-Up StudiesAgedRetinaTreatment Outcome